CBLN3抗体;CBLN3 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13027(CBLN3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The CBLN3 antibody is a research tool designed to detect and study Cerebellin-3 (CBLN3), a member of the cerebellin protein family. CBLN3 is a secreted glycoprotein implicated in synaptic organization and neurotransmission, particularly within the central nervous system. It shares structural homology with other cerebellin family members (CBLN1-4), which are known to interact with presynaptic neurexins and postsynaptic glutamate receptors, facilitating synapse formation and plasticity in glutamatergic circuits. While CBLN1 has been extensively studied in cerebellar function, CBLN3's precise biological role remains less defined, though it is hypothesized to contribute to synaptic adhesion and signaling in specific brain regions.

Antibodies targeting CBLN3 enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like immunohistochemistry, Western blotting, or immunofluorescence. These studies are critical for understanding its involvement in neural development, synaptic maintenance, and potential links to neurological or psychiatric disorders. Emerging evidence suggests CBLN3 may influence behaviors related to reward pathways or cognitive processing, with dysregulation observed in models of schizophrenia or autism spectrum disorders. However, further validation of antibody specificity and functional studies are needed to clarify its molecular mechanisms and therapeutic relevance. Commercial CBLN3 antibodies are typically raised in rabbits or mice, with validation in knockout controls recommended to ensure reliability.