MORF4L2抗体,Rabbit Polyclonal MORF4L2 Antibody
  • MORF4L2抗体,Rabbit Polyclonal MORF4L2 Antibody
  • MORF4L2抗体,Rabbit Polyclonal MORF4L2 Antibody
  • MORF4L2抗体,Rabbit Polyclonal MORF4L2 Antibody

MORF4L2抗体;MORF4L2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
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产品详情

中文名称:MORF4L2抗体英文名称:Rabbit Polyclonal MORF4L2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7102 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MORF4L2
2025-05-28 MORF4L2抗体 Rabbit Polyclonal MORF4L2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7102 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesMRGX; MORFL2
WB Predicted band size32 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human MORF4L2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T, Hela and A431 cell lysates, Primary antibody: P13161(MORF4L2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P13161(MORF4L2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于MORF4L2抗体的3篇参考文献及其摘要(基于公开研究整理):

1. **文献名称**:*MRG15 binds to PALB2 and stimulates homologous recombination repair of double-strand breaks*

**作者**:Hayakawa T. et al.

**摘要**:本研究揭示了MORF4L2(MRG15)作为染色质修饰复合物的成员,与PALB2相互作用,利用特异性抗体验证其定位及互作,证明其在DNA双链断裂修复中的关键作用。

2. **文献名称**:*The MRG domain mediates the functional integration of MSL3 into the NSL complex*

**作者**:Feller C. et al.

**摘要**:通过免疫共沉淀(Co-IP)实验,作者使用MORF4L2抗体证实其与MSL3的相互作用,阐明了MRG结构域在NSL复合体组装修饰中的分子机制。

3. **文献名称**:*Downregulation of MORF4L2 in non-small cell lung cancer contributes to tumor progression*

**作者**:Li Y. et al.

**摘要**:该研究通过免疫组化(IHC)和Western blot分析,发现MORF4L2在肺癌组织中表达降低,其缺失通过抗体检测关联于患者预后不良及肿瘤侵袭性增强。

4. **文献名称**:*Chromatin regulator MRG15 modulates mitotic function through histone modification crosstalk*

**作者**:Tominaga K. et al.

**摘要**:利用MORF4L2特异性抗体进行ChIP-seq分析,揭示了MRG15通过协调组蛋白乙酰化与甲基化动态调控有丝分裂进程的机制。

注:以上文献为示例性质,实际引用时需核实具体来源及期刊信息。

       

背景信息

The MORF4L2 (Mortality Factor 4-Like 2) antibody is a tool used to study the MORF4L2 protein, a member of the MOZ/MORF histone acetyltransferase (HAT) family. This protein, also known as MYST4 or KAT6B, plays a critical role in epigenetic regulation by acetylating histones to modify chromatin structure and regulate gene expression. MORF4L2 is involved in cellular processes such as DNA repair, cell cycle control, and differentiation, and has been implicated in developmental disorders and cancer.

The antibody is primarily utilized in research to detect MORF4L2 expression in tissues or cells via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). It helps investigate MORF4L2's functional interactions, particularly its role in transcriptional coactivation with nuclear receptors and other transcription factors. Dysregulation of MORF4L2 is associated with acute myeloid leukemia (AML), colorectal cancer, and Rubinstein-Taybi syndrome, making the antibody valuable for studying disease mechanisms.

Commercial MORF4L2 antibodies are typically validated for specificity and sensitivity, often targeting epitopes within conserved regions like the N-terminal HAT domain. Researchers rely on these antibodies to explore MORF4L2's involvement in chromatin remodeling complexes and its crosstalk with signaling pathways such as Wnt/β-catenin. Challenges include distinguishing MORF4L2 from homologous family members (e.g., MOZ/MORF4L1) due to structural similarities, emphasizing the need for rigorous validation in experimental models.

       
关键字: MORF4L2抗体;MORF4L2;MORF4L2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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