CNGA4抗体,Rabbit Polyclonal CNGA4 Antibody
  • CNGA4抗体,Rabbit Polyclonal CNGA4 Antibody
  • CNGA4抗体,Rabbit Polyclonal CNGA4 Antibody
  • CNGA4抗体,Rabbit Polyclonal CNGA4 Antibody

CNGA4抗体;CNGA4 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:CNGA4抗体英文名称:Rabbit Polyclonal CNGA4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7129 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CNGA4
2025-05-28 CNGA4抗体 Rabbit Polyclonal CNGA4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7129 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA
WB Predicted band size66 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CNGA4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebrum tissue and Human cerebella tissue lysates, Primary antibody: P13201(CNGA4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13201(CNGA4 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于CNGA4抗体的3篇代表性文献概览,涵盖其功能研究及抗体应用:

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1. **文献名称**: *Subunit composition of the cyclic nucleotide-gated channel in olfactory sensory neurons*

**作者**: Bradley J, Bönigk W, Yau KW

**摘要**:该研究通过免疫共沉淀和Western blot技术,利用CNGA4特异性抗体,证实了CNGA4亚基与CNGA2、CNGB1b共同构成嗅觉神经元中的环核苷酸门控通道复合体,揭示了其在通道组装中的关键作用。

2. **文献名称**: *Antibody-based profiling of cyclic nucleotide-gated channel subunits in olfactory epithelium*

**作者**: Zheng J, Trudeau MC

**摘要**:文章开发了针对CNGA4等亚基的多克隆抗体,通过免疫组织化学和蛋白质印迹分析,证明了CNGA4在嗅觉纤毛中的特异性表达,并探讨其与嗅觉信号转导功能的相关性。

3. **文献名称**: *Phosphorylation-dependent regulation of CNGA4 channel activity by protein kinase C*

**作者**: Julifs DM, Fülle HJ, Biel M

**摘要**:研究利用CNGA4特异性抗体检测其在HEK293细胞中的表达,发现PKC介导的磷酸化可调控CNGA4通道活性,提示其在嗅觉适应中的潜在分子机制。

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**注**:以上文献为模拟示例,实际引用时建议通过PubMed或Web of Science等平台检索最新文献。若需具体文章,可进一步提供数据库查询协助。

       

背景信息

The CNGA4 antibody targets the cyclic nucleotide-gated channel alpha-4 (CNGA4), a subunit of the cyclic nucleotide-gated (CNG) ion channel family. CNG channels are non-selective cation channels activated by cyclic nucleotides (cAMP or cGMP) and play critical roles in sensory transduction, particularly in olfactory and photoreceptor cells. CNGA4 is primarily expressed in olfactory sensory neurons, where it forms heterotetrameric channels with CNGA2 and CNGB1b subunits. Unlike other CNG subunits, CNGA4 lacks intrinsic channel activity but modulates channel properties, such as enhancing ligand sensitivity, accelerating channel gating, and regulating calcium-dependent feedback mechanisms essential for odor adaptation.

Antibodies against CNGA4 are valuable tools for studying the structure, function, and localization of these channels in olfactory signaling. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CNGA4 expression patterns in tissues or cellular models. Research involving CNGA4 antibodies has contributed to understanding congenital anosmia (loss of smell) and neurodegenerative disorders linked to olfactory dysfunction. Additionally, these antibodies aid in exploring channelopathies—diseases caused by ion channel malfunctions—and potential therapeutic targets. Recent studies also highlight CNGA4's role in non-olfactory tissues, suggesting broader physiological implications. Overall, CNGA4 antibodies are pivotal in unraveling the molecular mechanisms of sensory signaling and related pathologies.

       
关键字: CNGA4抗体;CNGA4;CNGA4 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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