EFNA2抗体;EFNA2 Antibody—艾普蒂

The EFNA2 antibody is a key tool for studying the Ephrin-A2 (EFNA2) protein, a member of the ephrin family that binds to Eph receptors to mediate cell-cell communication. EFNA2. a glycosylphosphatidylinositol (GPI)-anchored ligand, primarily interacts with EphA receptors to regulate bidirectional signaling pathways involved in developmental processes, including angiogenesis, axon guidance, and tissue patterning. Dysregulation of EFNA2 is linked to pathologies such as cancer metastasis, vascular disorders, and neurological diseases. The EFNA2 antibody enables detection and quantification of EFNA2 expression in various experimental models, facilitating research into its role in tumor microenvironments, endothelial cell migration, and neural network formation. It is commonly used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Studies utilizing this antibody have highlighted EFNA2's dual role in both promoting and inhibiting cancer progression, depending on context, as well as its contribution to vascular remodeling. Validation of the antibody typically includes specificity tests via knockout controls or siRNA knockdown. Ongoing research focuses on EFNA2's potential as a therapeutic target, particularly in anti-angiogenic therapies and precision oncology.