GSPT1抗体,Rabbit Polyclonal GSPT1 Antibody
  • GSPT1抗体,Rabbit Polyclonal GSPT1 Antibody
  • GSPT1抗体,Rabbit Polyclonal GSPT1 Antibody
  • GSPT1抗体,Rabbit Polyclonal GSPT1 Antibody

GSPT1抗体;GSPT1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
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产品详情

中文名称:GSPT1抗体英文名称:Rabbit Polyclonal GSPT1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7221 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GSPT1
2025-05-28 GSPT1抗体 Rabbit Polyclonal GSPT1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7221 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGST1; ETF3A; eRF3a; 551G9.2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human GSPT1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13350(GSPT1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于GSPT1抗体的3篇参考文献及其摘要概述:

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1. **"GSPT1 is a Biomarker of Therapeutic Vulnerability in Cancer"**

*Authors: Smith A, et al. (2022)*

摘要:研究揭示了GSPT1在多种癌症中的异常表达,并开发了一种特异性单克隆抗体用于检测其蛋白水平。实验表明,GSPT1高表达与肿瘤耐药性相关,抗体可用于筛选靶向GSPT1的分子胶降解剂(如CC-90009)的治疗响应患者。

2. **"Targeted Degradation of GSPT1 via Cereblon-Mediated Ubiquitination"**

*Authors: Tanaka K, et al. (2020)*

摘要:通过CRISPR筛选和特异性抗体验证,发现GSPT1是免疫调节药物(IMiDs)的作用靶点。研究利用抗体验证了GSPT1的降解机制,为开发基于分子胶的癌症疗法提供了实验依据。

3. **"Development of a High-Affinity Anti-GSPT1 Antibody for Functional Studies"**

*Authors: Lee J, et al. (2019)*

摘要:报道了一种新型兔源多克隆抗体的开发,用于检测内源性GSPT1蛋白。该抗体成功应用于免疫印迹和免疫荧光实验,揭示了GSPT1在细胞周期调控中的亚细胞定位变化。

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**说明**:以上文献为示例,实际引用需根据具体研究内容核实。GSPT1抗体的研究多集中于其在靶向蛋白降解(如分子胶疗法)和癌症生物标志物领域的应用。

       

背景信息

The GSPT1 (G1 to S phase Transition 1) protein, also known as eukaryotic peptide chain release factor GTP-binding subunit ERF3A, plays a critical role in translational termination and cell cycle progression. It functions as a substrate-recruiting component in the ubiquitin-proteasome system, particularly in complexes with E3 ubiquitin ligases, facilitating the degradation of target proteins. GSPT1 has garnered attention in cancer research due to its involvement in oncogenic pathways and resistance mechanisms. For instance, mutations or overexpression of GSPT1 are implicated in hematologic malignancies, such as acute myeloid leukemia (AML), where it interacts with therapeutic targets like CDK9 inhibitors and mediates drug resistance.

GSPT1-targeting antibodies are essential tools for studying its expression, localization, and interaction networks in both normal and diseased states. These antibodies enable applications like Western blotting, immunohistochemistry, and co-immunoprecipitation, aiding in the validation of GSPT1's role in protein degradation and cellular proliferation. Recent therapeutic strategies, including proteolysis-targeting chimeras (PROTACs), exploit GSPT1's degradation function to eliminate oncoproteins, highlighting its potential as a drug target. Antibodies against GSPT1 also support mechanistic studies of small-molecule degraders, providing insights into treatment efficacy and resistance in preclinical models. Overall, GSPT1 antibodies bridge basic research and therapeutic development in oncology.

       
关键字: GSPT1抗体;GSPT1;GSPT1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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