SLC6A11抗体;SLC6A11 Antibody—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A172 cell lysate , Primary antibody: P13437(SLC6A11 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

The solute carrier family 6 member 11 (SLC6A11) gene encodes the GABA transporter 3 (GAT-3), a transmembrane protein responsible for the reuptake of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. As part of the SLC6 family of sodium- and chloride-dependent transporters, GAT-3 regulates extracellular GABA levels, maintaining synaptic transmission balance and preventing excessive neuronal excitation. Dysregulation of GAT-3 has been implicated in neurological disorders, including epilepsy, anxiety, and sleep disturbances, making it a target for therapeutic research.

SLC6A11 antibodies are essential tools for studying the expression, localization, and function of GAT-3 in biological systems. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize protein distribution in brain tissues, particularly in astrocytes and specific neuronal populations. High-quality SLC6A11 antibodies exhibit specificity for epitopes in the C-terminal or extracellular domains of GAT-3. often validated through knockout controls or siRNA knockdown experiments. Researchers utilize these antibodies to explore GABAergic signaling alterations in disease models, drug response studies, and comparative analyses across species. Commercial SLC6A11 antibodies are typically raised in rabbits or mice, with validation data provided for target applications. Their reliability supports ongoing investigations into neuropharmacology and pathophysiology linked to GABA transport mechanisms.