HLA-DMB抗体,Rabbit Polyclonal HLA-DMB Antibody
  • HLA-DMB抗体,Rabbit Polyclonal HLA-DMB Antibody
  • HLA-DMB抗体,Rabbit Polyclonal HLA-DMB Antibody
  • HLA-DMB抗体,Rabbit Polyclonal HLA-DMB Antibody

HLA-DMB抗体;HLA-DMB Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
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产品详情

中文名称:HLA-DMB抗体英文名称:Rabbit Polyclonal HLA-DMB Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7378 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HLA-DMB
2025-05-28 HLA-DMB抗体 Rabbit Polyclonal HLA-DMB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7378 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRING7; D6S221E
WB Predicted band size29 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HLA-DMB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell lysate, Primary antibody: P13576(HLA-DMB Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13576(HLA-DMB Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于HLA-DMB抗体的3篇参考文献示例,包含文献名称、作者及摘要概括:

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1. **文献名称**:*HLA-DMB is a chaperone for MHC class II molecules and regulates antigen presentation*

**作者**:Denzin LK, Cresswell P

**摘要**:该研究通过使用HLA-DMB特异性抗体进行免疫沉淀和功能阻断实验,揭示HLA-DMB作为分子伴侣参与MHC II类分子的肽段加载过程,并证明其缺失会导致抗原呈递功能受损。

2. **文献名称**:*Dysregulation of HLA-DMB expression in melanoma correlates with immune evasion*

**作者**:Johnson RM, Edelson RL

**摘要**:通过流式细胞术和免疫组化技术结合HLA-DMB抗体,研究发现黑色素瘤细胞中HLA-DMB表达下调,导致CD4+ T细胞活化减少,提示其在肿瘤免疫逃逸中的潜在作用。

3. **文献名称**:*Cytokine modulation of HLA-DMB in autoimmune thyroid disease*

**作者**:Kimura H, Davies TF

**摘要**:该文献利用HLA-DMB抗体检测甲状腺组织样本,发现干扰素-γ(IFN-γ)可显著上调甲状腺滤泡细胞的HLA-DMB表达,提示其与自身免疫性甲状腺炎的病理机制相关。

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以上文献为示例,实际引用时需核实具体来源及准确性。如需真实文献,建议通过PubMed或Google Scholar以关键词“HLA-DMB antibody”或“HLA-DMB function”检索。

       

背景信息

HLA-DMB (Human Leukocyte Antigen class II DM beta chain) is a critical component of the HLA-DM heterodimer, a non-classical MHC class II molecule essential for antigen presentation. Unlike classical MHC II proteins, HLA-DM does not bind antigens directly but acts as a chaperone to facilitate peptide loading onto MHC II molecules. It catalyzes the exchange of unstable peptides (such as CLIP fragments) for high-affinity antigens in endosomal compartments, ensuring proper antigen presentation to CD4+ T cells. This process is vital for initiating adaptive immune responses against pathogens and maintaining immune tolerance.

Antibodies targeting HLA-DMB are primarily used in research to investigate MHC II antigen presentation mechanisms, immune regulation, and disease associations. Dysregulation of HLA-DM function has been linked to autoimmune disorders (e.g., rheumatoid arthritis, type 1 diabetes), infectious diseases, and certain cancers. For example, reduced HLA-DMB expression in Hodgkin’s lymphoma correlates with impaired antigen presentation and immune evasion. Researchers employ HLA-DMB-specific monoclonal or polyclonal antibodies in techniques like Western blotting, flow cytometry, and immunohistochemistry to study protein expression, localization, and interactions in cell lines or tissue samples. These antibodies also help explore genetic polymorphisms in HLA-DMB and their clinical implications. Recent studies highlight its potential as a biomarker or therapeutic target, particularly in diseases with compromised MHC II pathways.

       
关键字: HLA-DMB抗体;HLA-DMB;HLA-DMB Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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