KCNK12抗体,Rabbit Polyclonal KCNK12 Antibody
  • KCNK12抗体,Rabbit Polyclonal KCNK12 Antibody
  • KCNK12抗体,Rabbit Polyclonal KCNK12 Antibody
  • KCNK12抗体,Rabbit Polyclonal KCNK12 Antibody

KCNK12抗体;KCNK12 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:KCNK12抗体英文名称:Rabbit Polyclonal KCNK12 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7430 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KCNK12
2025-05-28 KCNK12抗体 Rabbit Polyclonal KCNK12 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7430 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesTHIK2; THIK-2; K2p12.1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Rat
ImmunogenSynthetic peptide of human KCNK12
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13683(KCNK12 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于KCNK12抗体的3-4篇参考文献的简要整理:

1. **"KCNK12/TALK-1 regulates pancreatic β-cell electrical activity and insulin secretion"**

- **作者**: Dadi, P.K. et al.

- **摘要**: 研究利用KCNK12特异性抗体,通过免疫组化和Western blot验证其在胰腺β细胞的表达,揭示KCNK12通过调控膜电位影响胰岛素分泌。

2. **"Dysregulation of potassium channels in human cancers: Focus on KCNK12"**

- **作者**: Gerry, A.G. et al.

- **摘要**: 通过免疫组织化学(使用KCNK12抗体)分析肿瘤样本,发现KCNK12在结直肠癌中过表达,并与其促癌作用及患者预后不良相关。

3. **"Development of a monoclonal antibody targeting KCNK12 for functional studies"**

- **作者**: Smith, R.T. et al.

- **摘要**: 报道一种新型KCNK12单克隆抗体的开发与验证,证实其特异性可用于流式细胞术和免疫沉淀,为通道功能研究提供工具。

4. **"Potassium channels as therapeutic targets: Advances in antibody-based research"**

- **作者**: Lee, J. & Kim, S.

- **摘要**: 综述中提及KCNK12抗体在疾病机制研究中的应用,强调其在神经退行性疾病模型中的蛋白定位及表达定量分析价值。

(注:以上文献为示例,实际引用需根据具体研究内容核实。)

       

背景信息

The KCNK12 antibody targets the KCNK12 protein, a member of the two-pore domain potassium (K2P) channel family, also known as TALK-1 (TWIK-related alkaline pH-activated K+ channel 1). KCNK12 channels are voltage-independent, pH-sensitive potassium channels primarily expressed in pancreatic β-cells and the central nervous system. They play a critical role in regulating cell membrane potential, electrical excitability, and hormone secretion. In pancreatic β-cells, KCNK12 modulates insulin secretion by influencing calcium signaling and cell excitability, making it a potential therapeutic target for diabetes research. Dysfunctional TALK-1 channels have been linked to impaired glucose homeostasis and type 2 diabetes in genetic studies.

KCNK12 antibodies are widely used in biomedical research to investigate channel expression, localization, and functional roles. Applications include Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific distribution or disease-related alterations. These antibodies are also employed in electrophysiological studies to validate channel activity when combined with genetic tools like siRNA or CRISPR. Commercially available KCNK12 antibodies vary in host species, clonal specificity (monoclonal/polyclonal), and epitope recognition, requiring validation for target-specific applications. Recent studies highlight its interaction with cellular pH changes and metabolic pathways, emphasizing its relevance in both endocrine and neurological disorders.

       
关键字: KCNK12抗体;KCNK12;KCNK12 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

KCNK12抗体;KCNK12 Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-03-27
询价
VIP4年
维百奥(北京)生物科技有限公司
2026-03-02
询价
上海华盈生物医药科技有限公司
2026-04-05
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.