KDM2B抗体;KDM2B Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13694(KDM2B Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The KDM2B antibody is a crucial tool for studying the KDM2B protein, a member of the lysine-specific histone demethylase family. KDM2B, also known as FBXL10 or JHDM1B, is an epigenetic regulator that catalyzes the removal of methyl groups from histone H3 lysine 36 (H3K36me2/me1) via its JmjC domain. This enzyme plays a dual role in gene regulation, either repressing or activating transcription depending on cellular context. It is involved in processes like ribosomal RNA gene silencing, stem cell maintenance, differentiation, and cellular senescence. Dysregulation of KDM2B has been linked to cancer progression, developmental disorders, and aging-related diseases.

The KDM2B antibody is widely used in techniques such as Western blotting, immunoprecipitation (IP), chromatin immunoprecipitation (ChIP), and immunofluorescence (IF) to detect protein expression, localization, and DNA-binding activity. Polyclonal and monoclonal antibodies targeting specific regions (e.g., N-terminal or C-terminal domains) are commercially available, often validated in knockout/knockdown models to ensure specificity. Researchers employ these antibodies to explore KDM2B's role in chromatin remodeling, its interaction with polycomb repressive complexes, and its impact on oncogenic or tumor-suppressive pathways. Proper validation using controls is critical due to potential cross-reactivity with homologous proteins like KDM2A.