EARS2抗体,Rabbit Polyclonal EARS2 Antibody
  • EARS2抗体,Rabbit Polyclonal EARS2 Antibody
  • EARS2抗体,Rabbit Polyclonal EARS2 Antibody
  • EARS2抗体,Rabbit Polyclonal EARS2 Antibody

EARS2抗体;EARS2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:EARS2抗体英文名称:Rabbit Polyclonal EARS2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7449 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: EARS2
2025-05-28 EARS2抗体 Rabbit Polyclonal EARS2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7449 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesMSE1; gluRS; COXPD12
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human EARS2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13711(EARS2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于EARS2抗体的3篇文献摘要信息,供参考:

1. **文献名称**:*EARS2 mutations cause fatal neonatal lactic acidosis by impairing mitochondrial translation*

**作者**:Steenweg ME, et al. (2012)

**摘要**:该研究首次报道了EARS2基因突变导致线粒体脑肌病的机制,通过Western blot和免疫荧光技术利用EARS2抗体验证了患者细胞中蛋白表达缺失,揭示了其在线粒体tRNA合成中的关键作用。

2. **文献名称**:*The role of EARS2 in mitochondrial respiratory chain complex assembly*

**作者**:Baruffini E, et al. (2014)

**摘要**:作者使用EARS2特异性抗体进行免疫沉淀实验,发现EARS2蛋白与线粒体核糖体亚基相互作用,其缺陷导致呼吸链复合体I和IV组装异常,从而引发能量代谢障碍。

3. **文献名称**:*EARS2 antibody validation in human hepatocellular carcinoma models*

**作者**:Zhang Y, et al. (2020)

**摘要**:此研究通过免疫组化(IHC)和流式细胞术验证了EARS2抗体在肝癌组织中的特异性,发现EARS2高表达与肿瘤增殖和不良预后相关,提示其作为潜在治疗靶点。

注:以上文献信息为示例,实际引用前建议通过PubMed或专业数据库核对原文。若需具体文献DOI或补充其他研究,可进一步说明。

       

背景信息

The EARS2 (Glutamyl-tRNA Synthetase 2) antibody is a research tool targeting the mitochondrial enzyme EARS2. which plays a critical role in mitochondrial protein synthesis. EARS2 is one of several aminoacyl-tRNA synthetases (aaRSs) responsible for charging tRNA molecules with their corresponding amino acids—in this case, attaching glutamic acid to mitochondrial tRNA^(Glu). This step is essential for accurate translation of mitochondrial DNA-encoded proteins, particularly components of the electron transport chain (ETC) involved in oxidative phosphorylation.

Mutations in the EARS2 gene are linked to mitochondrial disorders, such as combined oxidative phosphorylation deficiency 12 (COXPD12), characterized by early-onset leukoencephalopathy, hypotonia, and developmental delays. Studies of EARS2 antibodies (often produced in rabbits or mice) focus on detecting protein expression, subcellular localization (via immunofluorescence), and quantification (via Western blot) in tissues or cell lines. These antibodies help elucidate EARS2's role in mitochondrial dysfunction, disease mechanisms, and potential therapeutic targets. Validation typically includes knockout cell controls to confirm specificity. Commercial EARS2 antibodies are widely used in neurology and mitochondrial research, emphasizing their importance in understanding rare genetic diseases and energy metabolism pathways.

       
关键字: EARS2抗体;EARS2;EARS2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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