Fatty acid-binding protein 9 (FABP9), also known as testis-FABP or PERF15. is a member of the intracellular lipid-binding protein family that facilitates the transport and metabolism of fatty acids. Primarily expressed in the male reproductive system, FABP9 is abundant in germ cells, particularly during late spermatogenesis, and is thought to play a critical role in sperm development, energy homeostasis, and membrane remodeling. Its structural features include a conserved β-barrel domain with a hydrophobic pocket for ligand binding, and it lacks transmembrane regions, functioning as a cytoplasmic protein.
FABP9 antibodies are essential tools for studying its localization, expression dynamics, and interactions in reproductive biology. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate FABP9's role in spermatogenesis, sperm maturation, and lipid metabolism. Studies using these antibodies have linked FABP9 dysfunction to male infertility, as its deficiency in models leads to abnormal sperm morphology, reduced motility, and compromised fertilization capacity. Additionally, FABP9 antibodies aid in exploring its potential as a biomarker for reproductive disorders or a target for contraceptive development. Research also highlights its interaction with peroxisomal proteins, suggesting a broader role in cellular lipid regulation. Overall, FABP9 antibodies are pivotal in unraveling the molecular mechanisms connecting lipid dynamics to male fertility and reproductive health. (Word count: 247)