RNF135抗体;RNF135 Antibody—艾普蒂

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     Western blot analysis using RNF135 mouse mAb against  Jurkat lysate    

  
  

The RNF135 antibody targets the RNF135 protein, a member of the E3 ubiquitin ligase family encoded by the *RNF135* gene. This protein plays a critical role in ubiquitination, a post-translational modification process that regulates protein degradation, trafficking, and signaling. RNF135 is implicated in diverse cellular functions, including DNA repair, immune response modulation, and cell cycle control. Research has linked it to pathologies such as cancer, viral infections, and neurodevelopmental disorders, with studies highlighting its role in oncogenesis through interactions with tumor suppressors like p53 or regulators of NF-κB signaling.

RNF135 antibodies are essential tools for investigating the protein's expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study RNF135's involvement in disease mechanisms. For instance, elevated RNF135 levels have been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target. Conversely, mutations in *RNF135* are associated with genetic syndromes like Fontaine progeroid syndrome, underscoring its importance in developmental biology.

Commercially available RNF135 antibodies vary in specificity (monoclonal/polyclonal) and host species (rabbit, mouse). Validation data, including reactivity across human, mouse, or rat samples, are crucial for experimental reliability. Ongoing research aims to clarify RNF135's dual roles in promoting or suppressing tumorigenesis, depending on cellular context, and its interplay with viral pathogens. These studies highlight RNF135 as a multifaceted protein with therapeutic potential in precision medicine.