HistoneH3(monomethylK18)抗体,Rabbit Monoclonal HistoneH3(monomethylK18) Antibody
  • HistoneH3(monomethylK18)抗体,Rabbit Monoclonal HistoneH3(monomethylK18) Antibody
  • HistoneH3(monomethylK18)抗体,Rabbit Monoclonal HistoneH3(monomethylK18) Antibody
  • HistoneH3(monomethylK18)抗体,Rabbit Monoclonal HistoneH3(monomethylK18) Antibody

HistoneH3(monomethylK18)抗体;HistoneH3(monomethylK18) Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-29
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产品详情

中文名称:HistoneH3(monomethylK18)抗体英文名称:Rabbit Monoclonal HistoneH3(monomethylK18) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7874 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HistoneH3(monomethylK18)
2025-05-29 HistoneH3(monomethylK18)抗体 Rabbit Monoclonal HistoneH3(monomethylK18) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7874 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesH3 histone; HIST1H3A; Histone cluster 1, H3a; H3K18me1;;MonoMethyl-Histone H3 (K19)
WB Predicted band size15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Histone H3.1 around the methylation site of K19
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Histone H3 (mono methyl K18) expression in HeLa cell lysate.    


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       All lanes use the Antibody at 1:2k dilution for 1 hour at room temperature.    


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       Immunohistochemical analysis of paraffin-embedded human liver, using Histone H3 (mono methyl K18) Antibody.    


           

参考文献

以下是关于Histone H3 (monomethyl K18) 抗体的3篇参考文献及其摘要内容:

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1. **文献名称**:*"Site-specific methylation of histone H3K18 promotes DNA damage response initiation"*

**作者**:Smith ER, et al.

**摘要**:该研究揭示了组蛋白H3第18位赖氨酸单甲基化(H3K18me1)在DNA损伤应答中的调控作用。通过开发特异性抗体,作者证明H3K18me1在DNA损伤位点富集,并促进ATM激酶介导的修复信号传导。

2. **文献名称**:*"Dynamic regulation of histone H3K18 methylation during cell cycle progression"*

**作者**:Li B, et al.

**摘要**:本文利用H3K18me1特异性抗体,通过免疫荧光和ChIP-seq技术,揭示了该修饰在细胞周期中的动态变化。研究发现H3K18me1在G1期显著富集于异染色质区域,可能参与维持基因组稳定性。

3. **文献名称**:*"H3K18 monomethylation marks active enhancers in embryonic stem cells"*

**作者**:Zhao Y, et al.

**摘要**:该研究通过H3K18me1抗体结合染色质分析,发现该修饰特异性地标记胚胎干细胞中的活跃增强子区域,并调控多能性相关基因的表达,提示其在细胞命运决定中的表观遗传功能。

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注:以上文献信息为示例性内容,实际文献需通过PubMed或学术数据库检索确认具体标题及作者。如需真实文献,可搜索关键词“H3K18me1 antibody”或“histone H3 monomethylation K18”获取相关研究。

       

背景信息

The histone H3 monomethylated at lysine 18 (H3K18me1) antibody is a critical tool for studying epigenetic regulation linked to gene expression and chromatin dynamics. Histone H3. a core component of nucleosomes, undergoes post-translational modifications (PTMs) such as methylation, which influence DNA accessibility and transcriptional activity. Monomethylation at lysine 18 (K18) is a conserved mark associated with both active and repressive chromatin states, depending on cellular context. H3K18me1 has been implicated in regulating developmental genes, maintaining stem cell pluripotency, and modulating DNA damage response pathways. Dysregulation of this mark is observed in cancers, where altered H3K18me1 levels correlate with tumor progression and patient prognosis.

This antibody specifically recognizes the monomethylated form of H3K18. distinguishing it from unmethylated, dimethylated, or trimethylated states. It is commonly used in techniques like Western blotting, chromatin immunoprecipitation (ChIP), and immunofluorescence to map H3K18me1 distribution across genomes or assess its abundance in cellular models. Researchers validate its specificity using knockout controls or competitive peptides. Studies employing this antibody have shed light on how H3K18me1 interacts with chromatin modifiers (e.g., SETD6 methyltransferase) and readers to orchestrate transcriptional programs. Its application continues to advance understanding of epigenetic mechanisms in development, disease, and therapeutic targeting.

       
关键字: HistoneH3(monomethyl;HistoneH3(monomethyl;HistoneH3(monomethyl;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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