HIF-1beta抗体;HIF-1beta Antibody—艾普蒂

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human colon, using HIF-1 beta Antibody .    

  
  

The hypoxia-inducible factor 1 beta (HIF-1β), also known as aryl hydrocarbon receptor nuclear translocator (ARNT), is a constitutively expressed subunit of the heterodimeric HIF-1 transcription factor. It partners with oxygen-sensitive HIF-1α (or other α-subunits like HIF-2α/3α) to regulate cellular responses to hypoxia. Unlike HIF-1α, which is degraded under normoxia, HIF-1β remains stable and shuttles between the cytoplasm and nucleus. Upon dimerization, the HIF-1 complex binds hypoxia-response elements (HREs) in target genes, activating pathways involved in angiogenesis, glycolysis, cell survival, and metastasis.

HIF-1β antibodies are critical tools for studying HIF-mediated signaling in cancer, ischemia, and inflammatory diseases. They enable detection of HIF-1β protein levels via Western blotting, immunoprecipitation, or immunofluorescence, and help differentiate its roles from HIF-1α in hypoxic adaptations. Since HIF-1β also interacts with other partners (e.g., AhR in xenobiotic metabolism), specific antibodies aid in delineating context-dependent functions. Validated HIF-1β antibodies are essential for confirming protein integrity in hypoxia-related research, drug discovery, and diagnostic assays. Their specificity is often confirmed using knockout models or siRNA-mediated silencing to ensure accurate interpretation of HIF pathway dynamics.