5T4抗体,Rabbit Monoclonal 5T4 Antibody
  • 5T4抗体,Rabbit Monoclonal 5T4 Antibody
  • 5T4抗体,Rabbit Monoclonal 5T4 Antibody
  • 5T4抗体,Rabbit Monoclonal 5T4 Antibody

5T4抗体;5T4 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-29
QQ交谈 微信洽谈

产品详情

中文名称:5T4抗体英文名称:Rabbit Monoclonal 5T4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7908 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: 5T4
2025-05-29 5T4抗体 Rabbit Monoclonal 5T4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7908 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesTPBG; 5T4; 5T4-AG; 5T4AG; 5T4 oncofetal antigen; M6P1; Trophoblast glycoprotein;;Trophoblast glycoprotein
WB Predicted band sizeCalculated MW: 46 kDa ; Observed MW: 80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Trophoblast glycoprotein
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of 5T4 expression in Caco-2 cell lysates.    


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       Immunohistochemical analysis of paraffin-embedded human uters cancer, using 5T4 Antibody.    


           

参考文献

以下是关于5T4抗体的模拟参考文献示例(基于学术研究常见方向,非真实文献):

1. **文献名称**:*Development of a Novel 5T4-Targeting Antibody-Drug Conjugate for Solid Tumors*

**作者**:Smith A, et al. (2020)

**摘要**:研究报道了一种新型5T4抗体-药物偶联物(ADCT-601)的开发,通过将抗5T4单克隆抗体与细胞毒素结合,在临床前模型中显著抑制了多种实体瘤的生长,并验证了其靶向特异性和安全性。

2. **文献名称**:*5T4-Specific CAR-T Cell Therapy in Ovarian Cancer: Preclinical Evaluation*

**作者**:Johnson R, et al. (2018)

**摘要**:构建靶向5T4抗原的CAR-T细胞,在体外和小鼠卵巢癌模型中显示出强效抗肿瘤活性,并揭示了5T4高表达与肿瘤侵袭性的相关性,为临床试验奠定基础。

3. **文献名称**:*5T4 as a Prognostic Marker and Therapeutic Target in Colorectal Cancer*

**作者**:Brown K, et al. (2005)

**摘要**:首次证实5T4在结直肠癌中高表达且与不良预后相关,使用抗5T4单克隆抗体可抑制肿瘤细胞迁移和转移,提示其作为治疗靶点的潜力。

4. **文献名称**:*Targeting 5T4 with Immunotoxins for Non-Small Cell Lung Cancer Therapy*

**作者**:Lee C, et al. (2022)

**摘要**:开发了一种抗5T4抗体与毒素蛋白的融合分子,在非小细胞肺癌模型中选择性杀伤5T4阳性肿瘤细胞,并评估了其体内安全性和有效性。

**注**:以上为模拟示例,实际文献需通过PubMed、Google Scholar等平台检索关键词“5T4 antibody”或“5T4 targeted therapy”获取。

       

背景信息

The 5T4 antibody targets the 5T4 oncofetal antigen, also known as trophoblast glycoprotein (TPBG), a cell surface glycoprotein overexpressed in various cancers but minimally expressed in healthy adult tissues. Initially identified in placental trophoblast cells during embryogenesis, 5T4 is re-expressed in malignancies such as colorectal, ovarian, gastric, and non-small cell lung cancers. Its role in tumor progression involves promoting epithelial-mesenchymal transition (EMT), metastasis, and immune evasion, making it a promising therapeutic target. Structurally, 5T4 contains leucine-rich repeats and N-glycosylation sites, facilitating interactions with extracellular matrix components and signaling pathways like Wnt/β-catenin.

Antibodies against 5T4. including monoclonal antibodies (e.g., A5B7) and antibody-drug conjugates (ADCs), aim to block tumor growth or deliver cytotoxic payloads directly to cancer cells. Preclinical studies highlight their potential to inhibit metastasis and enhance chemotherapy sensitivity. Additionally, 5T4-targeted CAR-T cell therapies and vaccines are under exploration. Despite promising early results, challenges remain, including tumor heterogeneity in 5T4 expression and optimizing therapeutic efficacy while minimizing off-target effects. Ongoing research focuses on combination strategies with immune checkpoint inhibitors or radiotherapy to amplify anti-tumor responses. Overall, 5T4 antibodies represent a versatile tool in oncology, bridging targeted therapy and immunotherapy paradigms.

       
关键字: 5T4抗体;5T4;5T4 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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