IntegrinalphaE抗体;IntegrinalphaE Antibody—艾普蒂 新品

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     Immunohistochemical analysis of paraffin-embedded human tonsil, using Integrin alpha E Antibody.    

  
  

Integrin alphaE (αE), also known as CD103. is a transmembrane protein subunit that pairs with integrin beta7 (β7) to form the αEβ7 heterodimer. This integrin is primarily expressed on immune cells, including intraepithelial lymphocytes (IELs) and subsets of dendritic cells, particularly those residing in mucosal tissues such as the gut, skin, and lungs. Its canonical ligand is E-cadherin, a cell adhesion molecule expressed on epithelial cells. The αEβ7 integrin mediates cell-cell adhesion by binding E-cadherin, facilitating the retention and positioning of immune cells within epithelial layers, which is critical for maintaining tissue-specific immune surveillance and homeostasis.

CD103 has gained attention in immunology due to its role in regulating immune responses in barrier tissues. In cancer research, CD103+ T cells are associated with improved prognosis in certain tumors, as their presence correlates with enhanced cytotoxic activity and immune infiltration. Conversely, in chronic inflammatory conditions, dysregulated αEβ7 expression may contribute to pathogenic lymphocyte retention in tissues. Antibodies targeting integrin alphaE are valuable tools for studying these processes, enabling researchers to block or detect αEβ7 interactions in experimental models. Therapeutic applications are also being explored, particularly in modulating localized immune responses in autoimmune diseases or enhancing T cell targeting in solid tumors. These antibodies often serve dual roles as research reagents and potential clinical candidates.