hnRNPC1+C2抗体;hnRNPC1+C2 Antibody—艾普蒂 新品

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     Western blot analysis of hnRNP C1/C2 expression in (1) HeLa cell lysate; (2) HepG2 cell lysate.    

  
  

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     All lanes use the Antibody at 1:5000 dilution for 1 hour at room temperature.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human colon, using hnRNP C1/C2 Antibody.    

  
  

The heterogeneous nuclear ribonucleoprotein C1+C2 (hnRNP C1/C2) antibody targets two closely related RNA-binding proteins, hnRNP C1 and C1/C2. which are critical components of the hnRNP complex involved in mRNA processing. These proteins, encoded by the *HNRNPC* gene, are produced through alternative splicing, resulting in two isoforms: the longer hnRNP C1 and the shorter hnRNP C2. Both isoforms share identical sequences except for a 13-amino acid insertion in C1. They play essential roles in RNA metabolism, including pre-mRNA splicing, transport, stability, and translation regulation by binding to uridine-rich sequences.

The hnRNP C1+C2 antibody is widely used to study their collective functions, as the isoforms often coexist and cooperate in cellular processes. Researchers employ this antibody in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate their localization and interactions in diverse contexts, such as cancer, neurodegeneration, and viral infection. Studies have linked hnRNP C dysregulation to diseases like amyotrophic lateral sclerosis (ALS) and colorectal cancer, highlighting its biological relevance.

Due to structural similarity, the antibody recognizes both isoforms, enabling broad detection. However, distinguishing their individual roles may require additional approaches. Validation via knockout/knockdown controls is critical to confirm specificity. Overall, this antibody serves as a key tool for exploring RNA-protein interactions and gene expression mechanisms.