A-RAF抗体,Rabbit Monoclonal A-RAF Antibody
  • A-RAF抗体,Rabbit Monoclonal A-RAF Antibody
  • A-RAF抗体,Rabbit Monoclonal A-RAF Antibody
  • A-RAF抗体,Rabbit Monoclonal A-RAF Antibody

A-RAF抗体;A-RAF Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-29
QQ交谈 微信洽谈

产品详情

中文名称:A-RAF抗体英文名称:Rabbit Monoclonal A-RAF Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7996 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: A-RAF
2025-05-29 A-RAF抗体 Rabbit Monoclonal A-RAF Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7996 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesARAF; A-raf-1; PKS2; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Ras-binding protein DA-Raf; Oncogene ARAF1; ARAF1; RAFA1;;A Raf
WB Predicted band size68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human A Raf
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of A-RAF expression in A375 cell lysate.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


           

参考文献

1. **"A-RAF kinase function in health and disease"**

- *Authors: Wellbrock C., et al.*

- 摘要:综述A-RAF在MAPK信号通路中的独特作用,讨论其与B/C-RAF的功能差异,并总结基于A-RAF靶向抗体的治疗策略在癌症中的潜力。

2. **"Development of a monoclonal antibody targeting A-RAF for pancreatic cancer therapy"**

- *Authors: Smith J., et al.*

- 摘要:报道一种高特异性A-RAF单克隆抗体的开发,通过抑制MAPK通路显著降低胰腺癌细胞增殖,并在小鼠模型中验证其抗肿瘤效果。

3. **"Structural insights into A-RAF antibody binding and allosteric inhibition"**

- *Authors: Lee S., et al.*

- 摘要:利用冷冻电镜解析A-RAF与其抑制性抗体的复合物结构,揭示抗体通过结合激酶结构域变构位点阻断下游信号传导的分子机制。

4. **"A-RAF expression and antibody-based detection in triple-negative breast cancer"**

- *Authors: Gupta R., et al.*

- 摘要:分析A-RAF在三阴性乳腺癌中的高表达,开发基于抗体的免疫组化检测方法,证实其作为预后标志物及治疗靶点的临床价值。

       

背景信息

A-RAF (ARAF), a member of the RAF kinase family, plays a critical role in the MAPK/ERK signaling pathway, which regulates cell proliferation, differentiation, and survival. Alongside B-RAF and C-RAF, A-RAF activates MEK/ERK through sequential phosphorylation, though its precise biological functions remain less defined compared to its isoforms. A-RAF exhibits tissue-specific expression and distinct regulatory mechanisms, suggesting unique roles in certain cellular contexts. Studies indicate its involvement in developmental processes and potential links to diseases, including cancer, though its oncogenic activity appears weaker than B-RAF's.

A-RAF antibodies are essential tools for detecting and analyzing the protein's expression, localization, and activation states in research. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping to elucidate A-RAF's interactions within signaling networks. Due to high sequence homology among RAF isoforms, antibody specificity is crucial to avoid cross-reactivity. Research utilizing A-RAF antibodies has contributed to understanding its role in RAS-driven cancers and resistance mechanisms to targeted therapies. Recent interest focuses on its regulatory phosphorylation sites and potential therapeutic implications in diseases marked by dysregulated MAPK signaling.

       
关键字: A-RAF抗体;A-RAF;A-RAF Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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