PGC1alpha/beta抗体;PGC1alpha/beta Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1000 dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1000 dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1000 dilution for 1 hour at room temperature.    

  
  

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     Immunofluorescent analysis  of hela cells using the Antibody at 1:150 dilution.    

  
  

PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and PGC1β are transcriptional coactivators central to mitochondrial biogenesis, energy metabolism, and adaptive thermogenesis. They regulate genes involved in oxidative phosphorylation, fatty acid oxidation, and gluconeogenesis by interacting with nuclear receptors (e.g., PPARs, ERRs) and transcription factors. PGC1α is highly expressed in tissues with high metabolic demands, such as brown adipose, skeletal muscle, and liver, while PGC1β shares overlapping functions but exhibits distinct tissue-specific roles. Both are implicated in metabolic diseases, neurodegeneration, and cancer.

Antibodies targeting PGC1α/β are essential tools for studying their expression, localization, and interactions. They enable detection via Western blot, immunofluorescence, immunohistochemistry, and co-immunoprecipitation, aiding research into metabolic regulation, mitochondrial dysfunction, and disease mechanisms. Due to structural similarities between PGC1α and PGC1β, some antibodies exhibit cross-reactivity, while others are isoform-specific. Validation using knockout controls or siRNA is critical to confirm specificity. These antibodies have advanced studies in diabetes, obesity, and aging-related disorders, highlighting their roles as metabolic master regulators. Commercial antibodies are typically raised against conserved epitopes, with reactivity across species (human, mouse, rat), but batch variability remains a consideration.