TBR1抗体;TBR1 Antibody—艾普蒂

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     Western blot analysis of TBR1 expression in human fetal brain lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

TBR1 (T-box brain protein 1) is a transcription factor belonging to the T-box gene family, which plays critical roles in brain development. It is particularly essential for the differentiation and laminar organization of neurons in the cerebral cortex, amygdala, and olfactory bulbs. During cortical development, TBR1 regulates the specification of glutamatergic projection neurons in deep cortical layers (e.g., layer VI) and is involved in axonal guidance and synaptic connectivity. Its expression is tightly associated with neuronal maturation, making it a key marker for studying cortical layer formation and neuronal subtype identity.

TBR1 antibodies are widely used in neuroscience research to identify and characterize specific neuronal populations, particularly in immunohistochemistry, immunofluorescence, and Western blotting. These antibodies target epitopes within the conserved T-box DNA-binding domain or other regions of the TBR1 protein, enabling visualization of its spatial and temporal expression patterns. Dysregulation of TBR1 has been linked to neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability, and epilepsy, often due to mutations in the *TBR1* gene. Consequently, TBR1 antibodies are valuable tools for investigating disease mechanisms, cortical malformations, and neural circuit assembly. Their specificity and reliability have made them indispensable in both developmental neurobiology and translational research aimed at understanding brain disorders.