PerilipinA抗体;PerilipinA Antibody—艾普蒂

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Perilipin A expression in human fetal liver lysate.    

  
  

PerilipinA (PLIN1) is a lipid droplet-associated protein critical for regulating lipid storage and metabolism in adipocytes. As a member of the PAT family (Perilipin, ADRP, TIP47), it coats the surface of lipid droplets, acting as a protective barrier against uncontrolled lipolysis by inhibiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL). Its phosphorylation in response to adrenergic signaling triggers lipolytic enzyme recruitment, enabling controlled lipid breakdown.

Anti-PLINA antibodies are essential tools for studying adipose biology, metabolic disorders, and cellular lipid dynamics. They enable detection of PLINA expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help differentiate adipocyte maturation stages, as PLINA expression increases during lipid droplet formation and adipocyte differentiation. Research applications include obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD) studies, where PLINA dysregulation is implicated.

Commercial PLINA antibodies are typically raised against specific epitopes (e.g., human PLINA N-terminus) and validated for cross-reactivity in common models (mice, rats). Validation ensures specificity, as PLINA shares structural homology with other PAT proteins. Reliable antibodies aid in exploring lipid storage mechanisms, therapeutic targets, and metabolic adaptations, making them indispensable in obesity-related research and diagnostic development.