HistoneH2B(formylK116)抗体,Rabbit Monoclonal HistoneH2B(formylK116) Antibody
  • HistoneH2B(formylK116)抗体,Rabbit Monoclonal HistoneH2B(formylK116) Antibody
  • HistoneH2B(formylK116)抗体,Rabbit Monoclonal HistoneH2B(formylK116) Antibody
  • HistoneH2B(formylK116)抗体,Rabbit Monoclonal HistoneH2B(formylK116) Antibody

HistoneH2B(formylK116)抗体;HistoneH2B(formylK116) Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
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产品详情

中文名称:HistoneH2B(formylK116)抗体英文名称:Rabbit Monoclonal HistoneH2B(formylK116) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8336 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HistoneH2B(formylK116)
2025-05-30 HistoneH2B(formylK116)抗体 Rabbit Monoclonal HistoneH2B(formylK116) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8336 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesHistone H2B;;Formyl-Histone H2B type 2E (K117)
WB Predicted band size14 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthesized peptide derived from human Histone H2B type 2E around the formylation site of K117
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Histone H2B (formyl K116) expression in HeLa cell lysate.    


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       All lanes use the Antibody at 1:2k dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:2k dilution for 1 hour at room temperature.    


           

参考文献

以下是关于Histone H2B(formylK116)抗体的示例参考文献(内容为模拟,建议通过学术数据库验证):

1. **文献名称**:*"Formylation of Histone H2B at Lysine 116 Links Oxidative Stress to Chromatin Remodeling"*

**作者**:Chen Y et al.

**摘要**:该研究首次报道组蛋白H2B在K116位点的甲酰化修饰,开发了特异性抗体并验证其在氧化应激条件下的动态变化,表明其可能通过调控染色质结构参与DNA损伤修复。

2. **文献名称**:*"A Novel Antibody for Detecting H2B formylK116 in Neurodegenerative Disease Models"*

**作者**:Smith J et al.

**摘要**:作者开发了一种高特异性的H2B formylK116抗体,应用于阿尔茨海默病模型小鼠脑组织,发现甲酰化水平与神经元DNA氧化损伤程度正相关。

3. **文献名称**:*"Histone H2B Formylation as a Biomarker for Apoptosis: Validation by CRISPR-Cas9 and Antibody-Based Assays"*

**作者**:Li R et al.

**摘要**:研究利用CRISPR-Cas9技术验证H2B formylK116修饰在细胞凋亡中的作用,并通过该抗体的免疫荧光染色显示其在线粒体应激中的定位变化。

4. **文献名称**:*"Epigenetic Regulation via H2BK116 Formylation in Inflammatory Responses"*

**作者**:Wang H et al.

**摘要**:该文献揭示了H2B formylK116在巨噬细胞炎症反应中的表观调控功能,通过ChIP-seq(使用该抗体)发现其富集于促炎基因启动子区域。

**注意**:以上为模拟示例,实际文献需通过PubMed、Google Scholar等平台以关键词“Histone H2B formylK116 antibody”或“H2BK116 formylation”检索。

       

背景信息

Histone H2B(formylK116) antibodies are specialized tools used to study post-translational modifications (PTMs) of histone H2B, specifically formylation at lysine 116 (K116). Histones, including H2B, play critical roles in chromatin organization and gene regulation. PTMs like formylation alter histone function by modulating chromatin structure or recruiting effector proteins. The formyl group (-CHO) at K116 is a relatively understudied modification, potentially linked to DNA damage response, transcriptional regulation, or oxidative stress pathways. This modification might arise from non-enzymatic chemical reactions (e.g., reactive oxygen species) or enzymatic processes, though its exact mechanism remains unclear.

Antibodies targeting formylK116 are essential for detecting this modification in experimental settings, such as Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP). They help researchers investigate its biological significance, including potential roles in genome stability, epigenetic signaling, or disease states like cancer. For example, aberrant histone formylation could influence chromatin dynamics in tumors or inflammatory conditions. However, cross-reactivity with similar PTMs (e.g., acetylation or methylation) must be ruled out during validation. Studies using these antibodies contribute to understanding how non-canonical histone modifications fine-tune cellular responses, bridging gaps between chromatin biology and metabolic or stress-related pathways.

       
关键字: HistoneH2B(formylK11;HistoneH2B(formylK11;HistoneH2B(formylK11;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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