MEIS2抗体;MEIS2 Antibody—艾普蒂

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     Western blot analysis of MEIS2 expression in HepG2 cell lysate.    

  
  

The MEIS2 antibody is a crucial tool in studying the MEIS2 protein, a member of the TALE (three-amino-acid-loop-extension) homeodomain family of transcription factors. MEIS2 plays pivotal roles in embryonic development, particularly in organogenesis, neurogenesis, and limb patterning. It interacts with HOX proteins and other cofactors to regulate gene expression, influencing cellular differentiation and tissue morphogenesis. Dysregulation of MEIS2 has been linked to developmental disorders, including intellectual disabilities, autism spectrum disorders, and congenital anomalies like cleft palate. It is also implicated in cancers, such as neuroblastoma and leukemia, where its aberrant expression may drive tumor progression.

The MEIS2 antibody is widely used in research to detect and quantify MEIS2 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It helps map MEIS2's spatial and temporal expression patterns in tissues, shedding light on its role in developmental pathways and disease mechanisms. Commercial MEIS2 antibodies are typically validated for specificity and sensitivity, though variability in isoforms (e.g., MEIS2A, MEIS2B) requires careful selection for experimental contexts. Recent studies also utilize MEIS2 antibodies in ChIP-seq to identify genome-wide binding sites, revealing its regulatory networks. Overall, this antibody is indispensable for unraveling MEIS2's biological functions and therapeutic potential.