KMT1B/SUV39H2抗体,Rabbit Monoclonal KMT1B/SUV39H2 Antibody
  • KMT1B/SUV39H2抗体,Rabbit Monoclonal KMT1B/SUV39H2 Antibody
  • KMT1B/SUV39H2抗体,Rabbit Monoclonal KMT1B/SUV39H2 Antibody
  • KMT1B/SUV39H2抗体,Rabbit Monoclonal KMT1B/SUV39H2 Antibody

KMT1B/SUV39H2抗体;KMT1B/SUV39H2 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:KMT1B/SUV39H2抗体英文名称:Rabbit Monoclonal KMT1B/SUV39H2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8471 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KMT1B/SUV39H2
2025-05-30 KMT1B/SUV39H2抗体 Rabbit Monoclonal KMT1B/SUV39H2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8471 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesH3 K9 HMTase 2; KMT1B; Su(var)3 9 homolog 2; Suv39h2;;KMT1B
WB Predicted band size47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human KMT1B
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

  •  

     

       Western blot analysis of KMT1B / SUV39H2 expression in (1) MOLT-4 cell lysate; (2) Human testis lysate.    


           

参考文献

以下是3篇与KMT1B/SUV39H2抗体相关的参考文献及其摘要概括:

---

1. **"Role of the SUV39H2 histone methyltransferase in heterochromatin formation"**

*Rea, S. et al. (2002). Nature*

- 研究SUV39H2在异染色质形成中的功能,通过特异性抗体验证其在哺乳动物细胞中催化H3K9三甲基化,并揭示其与HP1蛋白的相互作用。

2. **"SUV39H2 silencing enhances DNA damage sensitivity in cancer cells"**

*Liu, C. et al. (2015). Oncogene*

- 使用抗SUV39H2抗体进行Western blot和免疫荧光分析,发现其表达下调增加癌细胞对DNA损伤的敏感性,提示其作为癌症治疗靶点的潜力。

3. **"CRISPR-based screening identifies SUV39H2 as a regulator of viral latency"**

*Zhang, Y. et al. (2018). Cell Reports*

- 通过CRISPR筛选结合抗SUV39H2抗体验证,发现该酶通过修饰病毒基因组H3K9甲基化调控疱疹病毒潜伏感染。

---

注:KMT1B为SUV39H2的别名,上述文献均涉及该蛋白抗体的实验应用(如检测表达、定位或功能研究)。如需更多文献或DOI号,可进一步补充检索条件。

       

背景信息

The KMT1B/SUV39H2 antibody is a crucial tool for studying the SUV39H2 protein, a member of the SUV39 subfamily of histone methyltransferases (HMTs). SUV39H2. also known as KMT1B, catalyzes the trimethylation of histone H3 at lysine 9 (H3K9me3), a hallmark of transcriptionally repressive heterochromatin. This enzyme plays a pivotal role in epigenetic regulation, maintaining genomic stability, and silencing retrotransposons. It shares functional redundancy with its paralog SUV39H1 (KMT1A), though SUV39H2 exhibits distinct expression patterns, including higher activity in germ cells and during early development. Dysregulation of SUV39H2 has been implicated in cancer, aging, and developmental disorders due to its influence on chromatin structure and gene expression.

The antibody targeting SUV39H2 enables researchers to detect and quantify its expression, localization, and interaction partners in various experimental settings, such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Validated antibodies are essential for distinguishing SUV39H2 from related HMTs, given the high sequence homology within the SUV39 family. Specificity is often confirmed using knockout controls or siRNA knockdown. Studies employing this antibody have shed light on SUV39H2's role in X-chromosome inactivation, telomere maintenance, and cellular differentiation. Its application in disease models further highlights its potential as a therapeutic target or biomarker for conditions linked to epigenetic dysregulation.

       
关键字: KMT1B/SUV39H2抗体;KMT1B/SUV39H2;KMT1B/SUV39H2 Antibo;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

KMT1B/SUV39H2抗体;KMT1B/SUV39H2 Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
询价
上海切尔齐生物科技有限公司
2025-05-18
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-03-27
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.