Cullin4A抗体;Cullin4A Antibody—艾普蒂 新品

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     Western blot analysis of Cullin 4a expression in Hela cell lysate.    

  
  

The Cullin4A antibody is a crucial tool in studying the Cullin4A protein, a core component of the Cullin-RING E3 ubiquitin ligase (CRL4) complex. Cullin4A, encoded by the *CUL4A* gene, functions as a scaffold to assemble substrate receptors (e.g., DDB1) and RING-box proteins (e.g., ROC1), facilitating targeted ubiquitination of proteins for proteasomal degradation. This process regulates critical cellular pathways, including DNA repair, cell cycle progression, chromatin remodeling, and response to DNA damage. Dysregulation of Cullin4A is linked to genomic instability and diseases such as cancer, making it a focus in oncogenesis and therapeutic research.

Cullin4A antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interaction partners. They help validate Cullin4A's role in CRL4 complexes and its involvement in disease mechanisms. Antibodies are available as monoclonal or polyclonal forms, often validated for specificity across human, mouse, and rat samples. Researchers also utilize these antibodies to explore post-translational modifications (e.g., neddylation) that regulate Cullin4A activity. Given its association with disorders like Xeroderma pigmentosum and cancer subtypes, Cullin4A antibodies are vital for both basic research and potential biomarker development.