CD98抗体;CD98 Antibody—艾普蒂 新品

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     Western blot analysis of CD98 expression in HepG2 cell lysate.    

  
  

CD98. also known as SLC3A2 (solute carrier family 3 member 2), is a transmembrane glycoprotein that forms a heterodimer with light chains (e.g., SLC7A5/LAT1) to create the CD98 complex. This complex functions as a bidirectional amino acid transporter and plays a role in integrin-mediated cell adhesion, proliferation, and signaling. CD98 is highly expressed in activated immune cells, epithelial cells, and various cancers, making it a potential therapeutic and diagnostic target.

CD98 antibodies are tools used to detect or modulate CD98 activity. In research, they help study CD98’s role in amino acid transport, mTOR pathway activation, and immune regulation, particularly in T-cell activation and tumor microenvironment interactions. Clinically, anti-CD98 antibodies are explored in cancer therapy due to their ability to block pro-survival signaling in tumors or deliver cytotoxic agents via antibody-drug conjugates (ADCs). Some studies also link CD98 to autoimmune diseases, suggesting therapeutic potential in modulating immune responses.

Notably, CD98’s dual role in nutrient sensing and cell adhesion complicates its targeting. Antibodies must balance specificity to avoid disrupting essential physiological functions. Recent advances include humanized antibodies and bispecific formats aiming to enhance tumor selectivity or synergize with immune checkpoint inhibitors. Despite challenges, CD98 remains a compelling target in oncology and immunology research.