Galectin7抗体;Galectin7 Antibody—艾普蒂 新品

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     Western blot analysis of Galectin 7 expression in HACAT cell lysate.    

  
  

Galectin-7. a member of the galectin family of β-galactoside-binding proteins, is a 15-kDa protein encoded by the LGALS7 gene. Primarily expressed in stratified epithelial tissues, particularly the skin, it plays roles in cell-cell adhesion, apoptosis, and differentiation. Galectin-7 is unique among galectins due to its strict homodimeric structure and its regulation by p53. linking it to stress responses and tumor suppression. It is also known as p53-induced gene 1 (PIG1), reflecting its involvement in DNA damage repair pathways. Dysregulation of Galectin-7 has been implicated in cancer progression, with conflicting roles observed: it acts as a tumor suppressor in certain contexts (e.g., colorectal cancer) while promoting metastasis in others (e.g., melanoma). Additionally, it contributes to inflammatory skin disorders like psoriasis and wound healing processes.

Antibodies targeting Galectin-7 are critical tools for studying its localization, expression patterns, and functional mechanisms. They enable detection via techniques such as immunohistochemistry, Western blotting, and flow cytometry. Commercial antibodies are typically raised in rabbits or mice using recombinant human Galectin-7 epitopes. Validation remains challenging due to homology with other galectins, requiring rigorous specificity testing. Recent research explores Galectin-7 antibodies for therapeutic potential, particularly in blocking cancer cell invasion or modulating immune responses. However, its dualistic roles in different microenvironments underscore the need for context-specific antibody applications in both research and clinical settings.