CathepsinS抗体;CathepsinS Antibody—艾普蒂 新品

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     Western blot analysis of Cathepsin S expression in U87-MG cell lysate.    

  
  

Cathepsin S (CTSS) is a lysosomal cysteine protease belonging to the papain family, primarily involved in protein degradation and antigen presentation. It is expressed in immune cells like dendritic cells, macrophages, and B lymphocytes, where it cleaves the invariant chain (Ii) of MHC class II molecules, enabling antigen peptide loading and adaptive immune activation. Dysregulation of Cathepsin S is linked to autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis), cancer progression, and neurodegenerative disorders, making it a therapeutic target.

Cathepsin S antibodies are essential tools for detecting its expression, localization, and activity in research. These antibodies (polyclonal or monoclonal) are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its role in pathological processes. For instance, elevated Cathepsin S levels in tumor tissues correlate with metastasis and angiogenesis, while its inhibition shows potential in reducing inflammation. Commercial antibodies often target specific epitopes (e.g., human CTSS around 37 kDa) and are validated using knockout controls or recombinant proteins. Recent studies also explore Cathepsin S inhibitors and antibody-based therapies, highlighting its dual role as a biomarker and drug target in precision medicine.