DARC抗体;DARC Antibody—艾普蒂 新品

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     Western blot analysis of DARC expression in Human fetal liver lysate.    

  
  

The Duffy Antigen Receptor for Chemokines (DARC), also known as ACKR1 or CD234. is a transmembrane protein first identified in 1950 through studies on blood group antigens. It belongs to the atypical chemokine receptor family, lacking classical signaling activity but acting as a scavenger or decoy receptor. DARC is expressed on erythrocytes and endothelial cells, where it binds pro-inflammatory chemokines (e.g., CXCL1. CXCL8) and Plasmodium vivax malaria parasites.

The DARC gene exhibits a well-known polymorphism: many individuals of African descent lack erythrocyte DARC due to a promoter mutation (FY*B^ES), conferring resistance to P. vivax infection. This adaptation reflects evolutionary pressure from malaria-endemic regions. Beyond its role in malaria susceptibility, DARC regulates chemokine homeostasis, influencing inflammatory responses, angiogenesis, and tumor progression.

DARC antibodies, targeting extracellular epitopes, have research and clinical significance. They are used to determine Duffy blood group status in transfusion medicine, study malaria invasion mechanisms, and investigate DARC's immunomodulatory functions. Anti-DARC therapies are explored for conditions like cancers and inflammatory diseases, though clinical applications remain experimental. Recent studies also link DARC expression to HIV pathogenesis and COVID-19 severity, highlighting its multifaceted role in human health.