MC1Receptor抗体;MC1Receptor Antibody—艾普蒂 新品

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     Western blot analysis of MC1 Receptor expression in A375 cell lysate.    

  
  

The melanocortin 1 receptor (MC1R) is a G-protein-coupled receptor (GPCR) primarily expressed in melanocytes, where it regulates pigmentation by binding α-melanocyte-stimulating hormone (α-MSH). This interaction activates signaling pathways that stimulate melanin synthesis and determine the type of melanin produced (eumelanin vs. pheomelanin). MC1R variants are strongly associated with skin and hair color phenotypes, red hair, and susceptibility to ultraviolet (UV)-induced skin damage and melanoma. Dysfunctional MC1R signaling is linked to increased cancer risk due to reduced DNA repair capacity and oxidative stress responses.

MC1R antibodies are critical tools for studying receptor expression, localization, and function in both physiological and pathological contexts. They enable detection of MC1R in tissues (e.g., skin, hair follicles) via techniques like immunohistochemistry, Western blotting, or flow cytometry. Researchers also use these antibodies to investigate MC1R's role in melanoma progression, as altered receptor expression or activity may influence tumor behavior. Additionally, MC1R antibodies have therapeutic potential, with studies exploring their use in targeting melanoma cells or modulating immune responses. Challenges include ensuring antibody specificity due to MC1R's structural homology with other melanocortin receptors. Recent advances in GPCR-targeted therapies and personalized medicine have renewed interest in MC1R as a biomarker and therapeutic target in dermatology and oncology.