Loricrin抗体,Rabbit Monoclonal Loricrin Antibody
  • Loricrin抗体,Rabbit Monoclonal Loricrin Antibody
  • Loricrin抗体,Rabbit Monoclonal Loricrin Antibody
  • Loricrin抗体,Rabbit Monoclonal Loricrin Antibody

Loricrin抗体;Loricrin Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
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产品详情

中文名称:Loricrin抗体英文名称:Rabbit Monoclonal Loricrin Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8603 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Loricrin
2025-05-30 Loricrin抗体 Rabbit Monoclonal Loricrin Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8603 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesLOR; Loricrin; LRN;;Loricrin
WB Predicted band sizeCalculated MW: 26 kDa ; Observed MW: 38 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Loricrin
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Loricrin expression in Human skin cell lysate.    


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       Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma. -Journal of Investigative Dermatology    


           

参考文献

以下是关于Loricrin抗体的3篇参考文献,按研究主题和抗体应用方向整理:

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1. **文献名称**:*"Loricrin and involucrin expression is down-regulated during psoriasis"*

**作者**:Ishida-Yamamoto A., et al. (2011)

**摘要**:研究通过免疫组化分析Loricrin和Involucrin在银屑病皮肤中的表达变化,发现Loricrin抗体标记的表皮分化程度降低,提示其在皮肤屏障功能障碍中的作用。

2. **文献名称**:*"Targeted disruption of the murine loricrin gene results in abnormal epidermal differentiation"*

**作者**:Koch P.J., et al. (2000)

**摘要**:利用Loricrin抗体研究基因敲除小鼠的表皮表型,发现Loricrin缺失导致角质包膜结构异常,证实其对角质细胞终末分化的必要性。

3. **文献名称**:*"Characterization of a monoclonal antibody directed against human loricrin"*

**作者**:Hohl D., et al. (1993)

**摘要**:描述了一种特异性识别人源Loricrin的单克隆抗体的开发,验证其在Western blot和免疫荧光中的应用,并用于定位表皮颗粒层的Loricrin分布。

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**备注**:Loricrin抗体常用于研究表皮分化、皮肤屏障相关疾病(如鱼鳞病、银屑病)及转基因动物模型的表型分析,上述文献涵盖抗体开发、基础功能研究和疾病机制探索。

       

背景信息

Loricrin is a key structural protein essential for the formation of the epidermal cornified envelope, a critical component of the skin barrier. Expressed predominantly in the stratum granulosum of the epidermis, loricrin constitutes ~70% of the total protein mass in the cornified envelope. During terminal differentiation, it undergoes cross-linking with other proteins (e.g., involucrin, small proline-rich proteins) via transglutaminase-mediated bonds, contributing to the mechanical resilience and waterproofing properties of the outermost skin layers. This process is vital for protecting against environmental stressors, pathogens, and water loss.

Loricrin antibodies are immunological tools used to study epidermal differentiation and skin pathology. These antibodies specifically target loricrin epitopes, enabling researchers to visualize its expression and distribution in tissues through techniques like immunohistochemistry (IHC) or immunofluorescence (IF). They are particularly valuable in investigating skin disorders linked to barrier dysfunction, such as atopic dermatitis, psoriasis, and ichthyosis. Additionally, loricrin antibodies aid in characterizing genetically engineered mouse models with loricrin mutations, which mimic human conditions like Vohwinkel syndrome (a rare autosomal dominant disorder featuring hyperkeratosis and digital constrictions). Studies also utilize these antibodies to explore wound healing, keratinocyte differentiation pathways, and the impact of environmental factors on epidermal integrity. Their specificity and reliability make loricrin antibodies indispensable in dermatological and developmental biology research.

       
关键字: Loricrin抗体;Loricrin;Loricrin Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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