DNAPolymerasegamma抗体,Rabbit Monoclonal DNAPolymerasegamma Antibody
  • DNAPolymerasegamma抗体,Rabbit Monoclonal DNAPolymerasegamma Antibody
  • DNAPolymerasegamma抗体,Rabbit Monoclonal DNAPolymerasegamma Antibody
  • DNAPolymerasegamma抗体,Rabbit Monoclonal DNAPolymerasegamma Antibody

DNAPolymerasegamma抗体;DNAPolymerasegamma Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:DNAPolymerasegamma抗体英文名称:Rabbit Monoclonal DNAPolymerasegamma Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8607 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DNAPolymerasegamma
2025-05-30 DNAPolymerasegamma抗体 Rabbit Monoclonal DNAPolymerasegamma Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8607 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GABRB1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12574(GABRB1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12574(GABRB1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3-4条关于DNA Polymerase gamma(POLG)抗体的参考文献示例,包含文献名称、作者及简要摘要内容:

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1. **文献名称**: "Autoantibodies against DNA polymerase gamma in patients with paraneoplastic neurological syndromes"

**作者**: Engelsen, B. et al.

**摘要**: 该研究探讨了副肿瘤性神经综合征(PNS)患者血清中抗POLG抗体的存在及其临床意义,发现此类抗体可能与神经退行性变和线粒体功能障碍相关。

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2. **文献名称**: "POLG autoantibodies: A novel biomarker in mitochondrial disorders"

**作者**: Hadjivassiliou, M. et al.

**摘要**: 提出抗POLG抗体可作为线粒体疾病的潜在生物标志物,研究通过ELISA检测患者血清抗体水平,发现其与POLG基因突变导致的线粒体脑肌病相关。

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3. **文献名称**: "Detection of anti-DNA polymerase gamma antibodies in primary biliary cirrhosis"

**作者**: Westermann, C. et al.

**摘要**: 研究检测了原发性胆汁性胆管炎(PBC)患者中抗POLG抗体的频率,提示其可能参与自身免疫性肝病的病理机制,并与线粒体损伤有关。

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4. **文献名称**: "Antibody profiling in mitochondrial encephalomyopathy: Insights into POLG-associated autoimmunity"

**作者**: Lee, H. & DiMauro, S.

**摘要**: 分析线粒体脑肌病患者中的自身抗体谱,发现抗POLG抗体与POLG基因突变患者的神经系统症状严重程度呈正相关,可能影响疾病进展。

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**注意**:以上文献为示例性内容,实际引用时需核实具体文献信息及准确性。建议通过PubMed、Google Scholar等平台以关键词“POLG antibody”或“anti-DNA polymerase gamma”检索最新研究。

       

背景信息

DNA polymerase gamma (Pol γ) antibody is a crucial tool in studying mitochondrial DNA (mtDNA) replication and repair. Pol γ, encoded by the *POLG* gene, is the sole DNA polymerase responsible for replicating and repairing mtDNA in eukaryotic cells. It consists of a catalytic subunit (Pol γA) and an accessory subunit (Pol γB), which together ensure high-fidelity synthesis of mtDNA. Mutations in *POLG* are linked to mitochondrial disorders such as Kearns-Sayre syndrome, Alpers syndrome, and progressive external ophthalmoplegia, highlighting its essential role in mitochondrial function.

Antibodies targeting Pol γ are typically generated using recombinant proteins or synthetic peptides corresponding to conserved regions of Pol γA or Pol γB. These antibodies enable the detection, quantification, and localization of Pol γ in various tissues and cell types through techniques like Western blotting, immunohistochemistry, and immunofluorescence. They are vital for diagnosing *POLG*-related diseases, assessing protein expression levels in mitochondrial dysfunction studies, and investigating the impact of pathogenic mutations on Pol γ stability or activity.

Additionally, Pol γ antibodies support research into mtDNA maintenance mechanisms, aging, and chemotherapy-induced mitochondrial toxicity. Their specificity is often validated using knockout cell lines or competitive peptide-blocking assays. By facilitating the study of Pol γ's structure-function relationships and its interactions with other mitochondrial proteins, these antibodies contribute to advancing our understanding of mitochondrial biology and associated diseases.

       
关键字: DNAPolymerasegamma抗体;DNAPolymerasegamma;DNAPolymerasegamma A;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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