Placentallactogen抗体;Placentallactogen Antibody—艾普蒂

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     Western blot analysis of Placental lactogen expression in JAR cell lysate.    

  
  

Placental lactogen (PL), also known as human placental lactogen (hPL) or chorionic somatomammotropin, is a peptide hormone produced by the syncytiotrophoblast cells of the placenta during pregnancy. Structurally similar to growth hormone and prolactin, it plays a critical role in maternal metabolic adaptation, fetal growth, and mammary gland development. PL promotes nutrient availability by modulating insulin sensitivity, lipolysis, and glucose metabolism, ensuring adequate fetal energy supply. Its levels rise progressively throughout gestation, correlating with placental mass and function.

Antibodies targeting placental lactogen are essential tools in reproductive and endocrine research. They enable the detection and quantification of PL in maternal serum, placental tissue, or cell cultures, aiding studies on placental health, pregnancy complications (e.g., preeclampsia, intrauterine growth restriction), and hormonal regulation. Both monoclonal and polyclonal antibodies are utilized, often in immunoassays (ELISA, immunohistochemistry, Western blot) to assess PL expression patterns or dysfunction. Additionally, PL antibodies contribute to diagnostic applications, such as evaluating placental insufficiency or monitoring high-risk pregnancies. Recent research also explores their potential in understanding PL's role in gestational diabetes and lactation biology. Specificity and cross-reactivity with related hormones (e.g., growth hormone) remain key considerations in antibody validation to ensure accurate experimental or clinical interpretations.