IL18bindingprotein抗体;IL18bindingprotein Antibody—艾普蒂 新品

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     Western blot analysis of IL18 binding protein in HeLa cell lysate.    

  
  

Interleukin-18 binding protein (IL-18BP) is a naturally occurring soluble inhibitor of the pro-inflammatory cytokine IL-18. which plays a critical role in regulating immune responses. IL-18 binds to its receptor to activate downstream inflammatory pathways, contributing to conditions like autoimmune diseases, chronic inflammation, and cancer. IL-18BP neutralizes IL-18 by forming high-affinity complexes, preventing receptor engagement. Antibodies targeting IL-18BP are valuable tools for studying its expression, function, and interaction dynamics in both physiological and pathological contexts.

These antibodies are typically developed as monoclonal or polyclonal reagents, enabling applications such as ELISA, Western blotting, immunohistochemistry, or neutralizing assays. In research, they help elucidate IL-18BP's role in modulating IL-18-driven inflammation and its therapeutic potential. For instance, elevated IL-18BP levels are observed in certain cancers and inflammatory disorders, suggesting it may serve as a biomarker or therapeutic target. Conversely, blocking IL-18BP with antibodies could enhance IL-18 activity in contexts where boosting immune responses is beneficial, such as infection or cancer immunotherapy.

The development of IL-18BP antibodies also supports clinical investigations, including monitoring therapeutic IL-18BP administration in trials for autoimmune diseases like rheumatoid arthritis. Understanding IL-18BP-IL-18 interactions through antibody-based studies provides insights into immune regulation and informs strategies to balance inflammatory responses in disease management.