PlacentalProtein14/PAEP抗体;PlacentalProtein14/PAEP Antibody—艾普蒂 新品

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     Western blot analysis of Placental Protein 14 / PAEP expression in TPA-treated K562 cell lysate.    

  
  

Placental Protein 14 (PP14), also known as Progesterone-Associated Endometrial Protein (PAEP), is a glycoprotein belonging to the lipocalin family. It is primarily secreted by the endometrial glands during the secretory phase of the menstrual cycle and by placental trophoblasts during pregnancy. PAEP is implicated in maternal-fetal immune tolerance, embryo implantation, and modulation of inflammatory responses, likely through interactions with immune cells or signaling pathways. Its expression is progesterone-dependent, peaking in the mid-luteal phase and early gestation, suggesting roles in preparing the endometrium for pregnancy and maintaining uterine quiescence.

PAEP antibodies are tools used in research and diagnostics to study the protein’s expression, localization, and function. In reproductive medicine, these antibodies help investigate conditions like recurrent pregnancy loss, preeclampsia, or endometriosis, where PAEP levels may be dysregulated. Beyond reproduction, PAEP is overexpressed in certain cancers (e.g., breast, ovarian), and antibodies aid in exploring its potential as a biomarker or therapeutic target. Structural studies using PAEP antibodies have revealed its ability to bind small hydrophobic molecules (e.g., retinoids, fatty acids), though their physiological relevance remains unclear. Challenges include understanding PAEP’s dual roles in immune suppression and cancer progression. Current research focuses on its diagnostic utility and mechanisms in tissue-specific contexts.