NUDC抗体;NUDC Antibody—艾普蒂

NUDC (Nuclear Distribution Protein C) is a conserved eukaryotic protein involved in mitotic spindle organization, chromosome segregation, and nuclear migration during cell division. It interacts with the dynein-dynactin motor complex and microtubules, facilitating proper microtubule dynamics and mitotic progression. Dysregulation of NUDC is linked to chromosomal instability, developmental defects, and cancer progression.

NUDC antibodies are immunological tools developed to detect and study this protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate NUDC's role in cell cycle regulation, particularly in cancer research where its overexpression correlates with tumor aggressiveness and poor prognosis. Some studies also explore NUDC's involvement in neurological disorders due to its neuronal migration functions.

Commercial NUDC antibodies are typically raised in rabbits or mice using recombinant protein fragments or synthetic peptides as antigens. Validation includes testing in knockout cell lines or tissues to confirm specificity. Challenges remain in distinguishing isoforms or post-translationally modified forms. Recent research leverages these antibodies to dissect NUDC's emerging roles in viral infection responses and primary cilia function, highlighting its multifaceted cellular importance.