RIP2抗体;RIP2 Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of RIP2 in K562 cell lysate.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The RIP2 (Receptor-Interacting Protein 2) antibody is a key tool for studying RIP2. a serine/threonine kinase also known as RIPK2 or CARD3. RIP2 plays a critical role in innate and adaptive immune signaling, primarily through its interaction with nucleotide-binding oligomerization domain (NOD) receptors, NOD1 and NOD2. Upon detection of bacterial components (e.g., peptidoglycans), these receptors recruit RIP2 via caspase recruitment domain (CARD)-mediated interactions, activating downstream NF-κB and MAPK pathways to trigger inflammatory responses. Dysregulation of RIP2 is linked to autoimmune diseases, chronic inflammation, and cancer.

RIP2 antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect RIP2 expression, post-translational modifications (e.g., ubiquitination), and subcellular localization. They help elucidate RIP2’s role in signaling crosstalk, including its crosstalk with TLR and TNF receptor pathways. Researchers also utilize these antibodies to explore RIP2 inhibition as a therapeutic strategy in conditions like inflammatory bowel disease, rheumatoid arthritis, and sepsis.

As RIP2-deficient models show impaired immune responses, the antibody aids in validating genetic models and assessing tissue-specific RIP2 expression. Its relevance in both infectious and sterile inflammation underscores its importance in immunology and drug development research.