The eIF3e antibody is a crucial tool for studying eukaryotic translation initiation factor 3 subunit E (eIF3e), a component of the multi-protein eIF3 complex essential for initiating protein synthesis. eIF3e, also known as Int6. plays a role in ribosome-mRNA binding and regulation of translation. It contains a PCI (Proteasome, COP9. Initiation factor) domain, facilitating interactions within the eIF3 complex and other cellular machinery. Dysregulation of eIF3e has been linked to cancer, viral infections, and cellular stress responses, as it modulates the translation of specific mRNAs involved in proliferation and survival. Researchers use eIF3e antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess its expression, localization, and protein interactions. These antibodies help investigate eIF3e’s role in tumorigenesis, particularly in studies exploring its altered expression in breast, lung, and prostate cancers. Additionally, eIF3e antibodies aid in understanding viral mechanisms, as certain pathogens exploit eIF3e to hijack host translation. Validated for specificity across species (human, mouse, rat), these antibodies are vital for dissecting translational control pathways and their implications in disease.