Neurocan抗体,Rabbit Monoclonal Neurocan Antibody
  • Neurocan抗体,Rabbit Monoclonal Neurocan Antibody
  • Neurocan抗体,Rabbit Monoclonal Neurocan Antibody
  • Neurocan抗体,Rabbit Monoclonal Neurocan Antibody

Neurocan抗体;Neurocan Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:Neurocan抗体英文名称:Rabbit Monoclonal Neurocan Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8742 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Neurocan
2025-05-30 Neurocan抗体 Rabbit Monoclonal Neurocan Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8742 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesCspg3; Ncan; NEUR; Neurocan core protein;;Neurocan
WB Predicted band sizeCalculated MW: 143 kDa ; Observed MW: 130270 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Neurocan
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

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       Western blot analysis of Neurocan expression in Fetal brain cell lysate.    


  •  

     

       Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:3K dilution)    


           

参考文献

以下是关于Neurocan抗体的3篇参考文献及其摘要概括:

1. **文献名称**: "Purification and characterization of developmentally regulated chondroitin sulfate proteoglycans expressed in embryonic brain"

**作者**: Rauch U. et al.

**摘要**: 该研究纯化了胚胎大鼠脑中的Neurocan蛋白,并制备了特异性抗体。通过免疫化学分析,揭示了Neurocan在神经发育过程中的时空表达模式,证实其作为硫酸软骨素蛋白聚糖在中枢神经系统细胞黏附中的调控作用。

2. **文献名称**: "Neurocan is upregulated in injured brain and in cytokine-treated astrocytes"

**作者**: Asher R.A. et al.

**摘要**: 文章利用Neurocan抗体检测其在脑损伤后的表达变化,发现Neurocan在胶质瘢痕中显著上调,且炎性因子(如TGF-β)可诱导星形胶质细胞分泌Neurocan,提示其参与抑制轴突再生。

3. **文献名称**: "The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar"

**作者**: Matsui F. et al.

**摘要**: 通过免疫组化结合Neurocan抗体,研究证明Neurocan在慢性胶质瘢痕中由反应性星形胶质细胞持续表达,可能通过抑制神经元突触可塑性影响中枢神经系统的修复。

4. **文献名称**: "Binding of tenascin-R and neurocan to phosphacan creates a ternary complex influencing neurite extension"

**作者**: Milev P. et al.

**摘要**: 研究利用Neurocan抗体探究其与tenascin-R、phosphacan的相互作用,发现三者形成的复合物可调节神经元突触生长,为Neurocan在神经再生中的抑制机制提供了分子层面的解释。

这些文献均涉及Neurocan抗体的实验应用,涵盖发育、损伤修复及分子机制等领域。

       

背景信息

Neurocan antibodies are essential tools in neuroscience research, specifically targeting neurocan, a chondroitin sulfate proteoglycan (CSPG) predominantly expressed in the central nervous system (CNS). Neurocan, a member of the lectican family, plays critical roles during brain development by regulating neuronal migration, axon guidance, and synaptic plasticity. It is highly abundant in the extracellular matrix (ECM) of developing brains but decreases in adulthood, though its expression can be upregulated following CNS injury or in neurodegenerative conditions like Alzheimer’s or Parkinson’s disease. Neurocan interacts with other ECM components and cell surface receptors, influencing cell adhesion and signaling pathways.

Antibodies against neurocan enable researchers to detect and study its spatial-temporal distribution, functional interactions, and involvement in pathological processes. They are widely used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to visualize neurocan in tissue sections or cultured cells. These antibodies have been instrumental in exploring neurocan’s dual role: while it inhibits axonal regeneration post-injury by creating a growth-restrictive environment, it also supports neuroprotection and ECM remodeling. Additionally, neurocan antibodies aid in investigating its potential as a biomarker for neurological disorders and in evaluating therapeutic strategies targeting CSPGs to enhance neural repair. Most neurocan antibodies are raised against specific epitopes in its core protein, ensuring specificity across species like humans, mice, and rats.

       
关键字: Neurocan抗体;Neurocan;Neurocan Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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