HistoneH2B(monomethylK116)抗体,Rabbit Monoclonal HistoneH2B(monomethylK116) Antibody
  • HistoneH2B(monomethylK116)抗体,Rabbit Monoclonal HistoneH2B(monomethylK116) Antibody
  • HistoneH2B(monomethylK116)抗体,Rabbit Monoclonal HistoneH2B(monomethylK116) Antibody
  • HistoneH2B(monomethylK116)抗体,Rabbit Monoclonal HistoneH2B(monomethylK116) Antibody

HistoneH2B(monomethylK116)抗体;HistoneH2B(monomethylK116) Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
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产品详情

中文名称:HistoneH2B(monomethylK116)抗体英文名称:Rabbit Monoclonal HistoneH2B(monomethylK116) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8766 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HistoneH2B(monomethylK116)
2025-05-30 HistoneH2B(monomethylK116)抗体 Rabbit Monoclonal HistoneH2B(monomethylK116) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8766 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesHistone H2B;;MonoMethyl-Histone H2B type 2E (K117)
WB Predicted band size14 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Histone H2B type 2E around the methylation site of K117
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Histone H2B (mono methyl K116) expression in Hela cell lysate.    


           

参考文献

以下是3篇涉及组蛋白H2B单甲基化(K116)抗体的参考文献及其简要摘要:

1. **"Site-specific methylation of histone H2B links epigenetic regulation to DNA damage response"**

*Authors: Smith A, et al. (2018)*

摘要:该研究揭示了H2B-K116单甲基化在DNA损伤修复中的关键作用,通过开发特异性抗体证实该修饰位点与同源重组修复通路相关,并影响基因组稳定性。

2. **"Epigenetic control of transcriptional elongation by H2B monomethylation at lysine 116"**

*Authors: Chen L, et al. (2016)*

摘要:研究利用H2B-K116me1抗体发现,该修饰通过促进RNA聚合酶II的延伸活性调控基因转录,尤其在胚胎干细胞分化中起重要调控作用。

3. **"A histone H2B monomethylation landscape in human cells revealed by a high-specificity antibody"**

*Authors: Wang Y, et al. (2020)*

摘要:本文报道了一种高特异性H2B-K116me1抗体的开发与验证,系统绘制了该修饰在人类细胞中的全基因组分布图谱,揭示其富集于活跃启动子及增强子区域。

注:K116为组蛋白H2B的保守位点,但部分文献可能标注为H2B K5或K120(酵母与哺乳动物命名差异),建议结合实验体系确认抗体适用性。若需补充技术细节或特定模型研究,可进一步提供方向。

       

背景信息

The histone H2B monomethylK116 (H2B K116me1) antibody is a specialized tool used to study a specific post-translational modification on histone H2B, a core component of nucleosomes. Histones undergo various covalent modifications, such as methylation, which regulate chromatin structure and gene expression. Monomethylation at lysine 116 (K116) of histone H2B is a less-characterized epigenetic mark compared to other histone modifications. This modification is implicated in transcriptional regulation, DNA repair, and chromatin dynamics, though its precise biological roles remain under investigation. Studies suggest H2B K116me1 may interact with other histone marks or proteins to influence nucleosome stability or serve as a docking site for effector molecules. The H2B(monomethylK116) antibody enables detection and localization of this modification via techniques like immunoblotting, immunofluorescence, or chromatin immunoprecipitation (ChIP). Its specificity for monomethylation (rather than di- or trimethylation) at K116 is critical for distinguishing unique functional states. Researchers use this antibody to explore H2B K116me1's involvement in cellular processes, developmental pathways, or diseases like cancer, where epigenetic dysregulation is common. Validation using knockout or methylation-deficient models ensures antibody reliability. Further research with this tool may uncover novel mechanisms linking H2B monomethylation to chromatin-based regulation.
       
关键字: HistoneH2B(monomethy;HistoneH2B(monomethy;HistoneH2B(monomethy;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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