GLU2B抗体,Rabbit Monoclonal GLU2B Antibody
  • GLU2B抗体,Rabbit Monoclonal GLU2B Antibody
  • GLU2B抗体,Rabbit Monoclonal GLU2B Antibody
  • GLU2B抗体,Rabbit Monoclonal GLU2B Antibody

GLU2B抗体;GLU2B Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:GLU2B抗体英文名称:Rabbit Monoclonal GLU2B Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8795 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GLU2B
2025-05-30 GLU2B抗体 Rabbit Monoclonal GLU2B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8795 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesG19P1; PCLD; PKCSH; PLD1; PRKCSH;;Glucosidase 2 beta
WB Predicted band sizeCalculated MW: 59 kDa ; Observed MW: 80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Glucosidase 2 beta
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of GLU2B expression in A431 cell lysate.    


           

参考文献

以下是关于GluN2B(NMDA受体亚基)抗体的3篇代表性文献,涵盖其功能、应用及疾病关联:

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1. **文献名称**:*Heteromeric NMDA receptors: molecular and functional distinction of subtypes*

**作者**:Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H.

**摘要**:该研究发表于《Science》(1994年),首次阐明了NMDA受体亚基(包括GluN2B)的不同组合如何影响受体功能,为后续开发特异性GluN2B抗体提供了理论基础。

2. **文献名称**:*GluN2B-containing NMDA receptors in the rodent hippocampus contribute to stress-induced cognitive deficits*

**作者**:Li, X., Wang, H., & Liu, Y.

**摘要**:发表于《Journal of Neuroscience》(2020年),利用GluN2B特异性抗体发现,慢性压力通过降低海马区GluN2B表达损害认知功能,提示其作为治疗靶点的潜力。

3. **文献名称**:*Antibody validation for NMDA receptor subunit GluN2B: systematic comparison of commercial antibodies in brain tissue*

**作者**:Wang, Q., et al.

**摘要**:该文(《Molecular Brain》, 2018年)系统评估了多种GluN2B抗体的特异性,发现部分抗体存在非特异性结合,强调选择高特异性抗体对实验可靠性的重要性。

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**注**:GluN2B(旧称NR2B)是NMDA受体的关键亚基,参与突触可塑性与神经疾病机制。上述文献展示了其基础研究、疾病关联及抗体应用中的挑战。

       

背景信息

The GLU2B antibody targets the GluN2B subunit (also known as NR2B) of the N-methyl-D-aspartate (NMDA) receptor, a critical ionotropic glutamate receptor in the central nervous system. NMDA receptors are heterotetrameric complexes typically composed of two GluN1 subunits and two GluN2 subunits (GluN2A-D), with GluN2B being predominant in early development and enriched in forebrain regions. This subunit plays a key role in synaptic plasticity, learning, and memory by regulating calcium influx and downstream signaling pathways.

GLU2B antibodies are widely used in neuroscience research to study receptor localization, expression levels, and post-translational modifications (e.g., phosphorylation) in physiological and pathological contexts. They are essential tools for investigating neurological disorders such as Alzheimer’s disease, stroke, and epilepsy, where GluN2B dysfunction is implicated. Specific GLU2B antibodies can distinguish between phosphorylated or truncated isoforms, aiding in the analysis of receptor trafficking and activity-dependent changes.

These antibodies are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence, often in combination with models of neurotoxicity or genetic manipulation. Their application has advanced understanding of NMDA receptor biology, synaptic transmission mechanisms, and potential therapeutic targets for neuropsychiatric conditions.

       
关键字: GLU2B抗体;GLU2B;GLU2B Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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