Phospho-Tau (Ser202)抗体,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
  • Phospho-Tau (Ser202)抗体,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
  • Phospho-Tau (Ser202)抗体,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
  • Phospho-Tau (Ser202)抗体,Rabbit Monoclonal Phospho-Tau(Ser202) Antibody

Phospho-Tau (Ser202)抗体;Phospho-Tau (Ser202) Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-06-03
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产品详情

中文名称:Phospho-Tau (Ser202)抗体英文名称:Rabbit Monoclonal Phospho-Tau(Ser202) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8970 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Phospho-Tau (Ser202)
2025-06-03 Phospho-Tau (Ser202)抗体 Rabbit Monoclonal Phospho-Tau(Ser202) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8970 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF1/20 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliaseshK2; hGK-1; KLK2A2
Entrez GeneID3817
clone1C4H4
WB Predicted band size28.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human KLK2 (AA: 25-261) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of K562 cells using KLK2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using KLK2 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于Phospho-Tau (Ser202)抗体的代表性文献摘要:

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1. **文献名称**: *"Phosphorylation of Tau at Serine 202 in Alzheimer's Disease"*

**作者**: H. Braak et al.

**摘要**: 本研究通过免疫组化分析阿尔茨海默病患者脑组织,发现Phospho-Tau (Ser202)抗体能特异性识别早期神经原纤维缠结(NFTs),并揭示该位点磷酸化与疾病进展的相关性,提示其作为病理标志物的潜力。

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2. **文献名称**: *"Validation of Phospho-Tau (Ser202) as a Biomarker in Transgenic Tauopathy Models"*

**作者**: K. Ishihara et al.

**摘要**: 通过转基因小鼠模型验证Phospho-Tau (Ser202)抗体的特异性,证明其能检测到tau蛋白在Ser202位点的磷酸化,并与神经元功能障碍相关,为临床前研究提供了可靠工具。

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3. **文献名称**: *"Selective Detection of Pathological Tau Phosphorylation Using Conformation-Sensitive Antibodies"*

**作者**: P. Davies et al.

**摘要**: 开发了一种针对Ser202磷酸化tau的构象敏感抗体,该抗体能区分正常与异常折叠的tau蛋白,为阿尔茨海默病和其他tau蛋白病的分子机制研究提供了新方法。

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如果需要更具体的文献或补充DOI信息,可进一步说明!

       

背景信息

The Phospho-Tau (Ser202) antibody is a critical tool in neuroscience research, particularly for studying tauopathies like Alzheimer’s disease (AD). Tau is a microtubule-associated protein that stabilizes neuronal microtubules under normal conditions. Its dysfunction, often linked to abnormal phosphorylation, disrupts microtubule stability and promotes pathological aggregation into neurofibrillary tangles (NFTs), a hallmark of AD. Phosphorylation at specific residues, including serine 202 (Ser202), is a key regulatory mechanism influencing tau’s microtubule-binding affinity and aggregation propensity.

The Phospho-Tau (Ser202) antibody specifically detects tau phosphorylated at Ser202. a site hyperphosphorylated in pathological conditions. This epitope is part of the paired helical filament (PHF) tau found in NFTs and is recognized by the widely used AT8 antibody. Elevated phosphorylation at Ser202 correlates with disease progression, making this antibody valuable for diagnosing tauopathies, monitoring pathological changes in models, and evaluating therapeutic interventions targeting tau phosphorylation. It is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study post-translational modifications of tau in brain tissues, cell cultures, or transgenic animal models. Its specificity aids in distinguishing pathological tau from normal isoforms, providing insights into mechanisms underlying neurodegeneration.

       
关键字: Phospho-Tau (Ser202);Phospho-Tau (Ser202);Phospho-Tau (Ser202);

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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