Phospho-delta 1 Catenin (Ser268)抗体;Phospho-delta 1 Catenin (Ser268) Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Phospho-delta 1 Catenin/CAS (Ser268) in A549, MCF-7, U251, C2C12 lysates using Phospho-delta 1 Catenin (Ser268) antibody.    

  
  

The phospho-delta 1 Catenin (Ser268) antibody is a specialized tool used to detect delta-catenin (δ-catenin) when phosphorylated at serine residue 268. Delta-catenin, a member of the p120-catenin subfamily, plays critical roles in cell-cell adhesion, synaptic stability, and neuronal signaling. It interacts with cadherins, regulating their trafficking and stability at adherens junctions. Phosphorylation at Ser268 is a post-translational modification that modulates delta-catenin's functions, particularly in neural and cancer biology. This site-specific phosphorylation is implicated in altering protein-protein interactions, influencing synaptic plasticity, and contributing to pathological processes such as Alzheimer’s disease or tumor progression.

The antibody is commonly employed in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study delta-catenin activation states in cellular or tissue samples. Researchers use it to explore mechanisms underlying neurodevelopmental disorders, neurodegenerative diseases, or cancer metastasis, where dysregulated delta-catenin signaling is observed. Proper experimental controls, including non-phosphorylated delta-catenin detection and kinase inhibition studies, are essential to validate specificity. Understanding Ser268 phosphorylation dynamics helps elucidate how delta-catenin balances roles in cell adhesion, Wnt signaling, and cytoskeletal organization, offering insights into therapeutic targeting for related diseases.