Phospho-alpha Synuclein (Ser129)抗体;Phospho-alpha Synuclein (Ser129) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-alpha Synuclein (Ser129) in mouse brain lysates using Phospho-alpha Synuclein (Ser129) antibody.    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human brain using Synuclein (Phospho-Ser129) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.    

  
  

Phospho-alpha Synuclein (Ser129) antibodies are critical tools in studying the pathogenesis of neurodegenerative disorders, particularly Parkinson’s disease (PD) and other synucleinopathies. Alpha-synuclein (α-Syn) is a presynaptic protein implicated in synaptic vesicle regulation. In pathological conditions, it aggregates into insoluble fibrils, forming Lewy bodies and Lewy neurites—hallmark lesions in these diseases. Post-translational modifications, including phosphorylation at serine 129 (Ser129), are linked to α-Syn aggregation. Notably, over 90% of aggregated α-Syn in Lewy bodies is phosphorylated at Ser129. suggesting this modification plays a key role in disease progression.

Phospho-specific antibodies targeting Ser129 enable researchers to detect and quantify this modified form of α-Syn in experimental models and human tissues. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and ELISA to study phosphorylation dynamics in cellular and animal models of neurodegeneration. Their application has advanced understanding of how Ser129 phosphorylation influences α-Syn toxicity, aggregation, and clearance mechanisms.

Additionally, these antibodies hold diagnostic potential, as elevated phospho-Ser129 α-Syn levels in cerebrospinal fluid or blood are explored as biomarkers for early disease detection. However, debates persist about whether Ser129 phosphorylation promotes aggregation or represents a cellular protective response. Continued research using these antibodies may clarify its role and guide therapeutic strategies targeting α-Syn pathology.