Actin Related Protein 3抗体;Actin Related Protein 3 Antibody—艾普蒂 新品

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     Western blot analysis of Arp3 in K562, rat Brain, C6, 3T3, Hela lysates using Arp3 antibody.    

  
  

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     Immunocytochemistry analysis of Arp3(green) in Hela cells using Arp3 antibody,and DAPI(blue)    

  
  

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     Immunohistochemistry analysis of paraffin-embedded mouse colon using Actin Related Protein 3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

Actin-Related Protein 3 (ARP3) is a crucial subunit of the Arp2/3 complex, a conserved multi-protein assembly essential for nucleating and branching actin filaments in eukaryotic cells. This complex regulates cytoskeletal dynamics, enabling processes like cell motility, membrane trafficking, and cytokinesis. ARP3 antibodies are immunological tools designed to detect and study the expression, localization, and function of ARP3 in various biological contexts. These antibodies, often raised in rabbits or mice, are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate cytoskeletal reorganization in diseases like cancer, immune disorders, and neurodegenerative conditions.

Research utilizing ARP3 antibodies has highlighted its role in cancer metastasis, where aberrant Arp2/3 activity promotes invasive cell migration. They also aid in studying developmental defects linked to cytoskeletal dysregulation. Specificity is typically validated using knockout cell lines or siRNA-mediated depletion. Recent studies explore ARP3's interaction with nucleation-promoting factors (e.g., WASP, SCAR/WAVE) and its involvement in autophagy or pathogen infection mechanisms. As the Arp2/3 complex gains attention as a potential therapeutic target, ARP3 antibodies remain vital for dissecting its pathophysiological contributions across experimental models.