Human TREM-1 / CD354 Protein, Fc Tag
分子别名(Synonym)
TREM1,CD354
表达区间及表达系统(Source)
Human TREM-1, Fc Tag (TR1-H5251) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Arg 200 (Accession # Q9NP99-1).
Predicted N-terminus: Ala 21
蛋白结构(Molecular Characterization)

This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 46.7 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景介绍
髓系细胞触发受体1 (TREM1)(也称为CD抗原CD354)是一种具有单一Ig样结构域的I型跨膜蛋白。TREM1在成人肝脏、肺和脾脏中的表达水平高于相应的胎儿组织。
TREM-1 / CD354 能够刺激中性粒细胞和单核细胞介导的炎症反应,并触发促炎性趋化因子和细胞因子的释放,同时增加细胞活化标志物的表面表达。它是细菌和真菌感染引发的炎症反应的放大器,并且是脓毒性休克的关键介质。TREM1能够与TYROBP / DAP12(DNAX激活蛋白12)相互作用。
关键字: TREM-1;TREM-1蛋白;TREM-1重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。