Human TL1A / TNFSF15 Protein, His Tag, active trimer (MALS verified)
分子别名（Synonym）
TL1A, VEGI, TNFSF15
表达区间及表达系统（Source）
Human TL1A, His Tag (TLA-H5243) is expressed from human 293 cells (HEK293). It contains AA Leu 72- Leu 251 (Accession # O95150-1).
Predicted N-terminus: His
蛋白结构（Molecular Characterization）
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 22.4 kDa. The protein migrates as 26 kDa and 28-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度（Purity）
>90% as determined by SDS-PAGE.
制剂（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景介绍
肿瘤坏死因子样细胞因子1A（TL1A）及其受体死亡受体3（DR3）和诱饵受体3（DcR3）分别属于TNF超家族和TNF受体超家族蛋白。抗原呈递细胞衍生的TL1A与淋巴细胞DR3结合后，可为活化淋巴细胞提供共刺激信号。DR3信号传导不仅影响效应淋巴细胞的增殖活性与细胞因子分泌，更关键地调控着调节性T细胞的发育及其抑制功能。而DcR3则通过拮抗TL1A/DR3复合物功能，减弱T细胞活化并下调促炎细胞因子的分泌。TL1A与DR3、DcR3共同构成一个主动干预免疫应答调控的细胞因子系统。
关键字： TL1A;TL1A蛋白;TL1A重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group（股票代码：301080）是成立于2010年的跨国生物科技公司，是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球，横跨亚洲、北美洲、欧洲，在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家，与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。