Human Glypican 3 / GPC3 Protein, His Tag, premium grade
分子别名(Synonym)
GPC3, OCI5, Glypican-3, GTR2-2, MXR7, DGSX, SDYS , SGB, SGBS, SGBS1
表达区间及表达系统(Source)
Human Glypican 3, His Tag, premium grade (GP3-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - His 559 (Accession # P51654-1).
Predicted N-terminus: Gln 25 & Ser 359
该产品在我们严格的质量控制体系下生产,包含无菌检测、内毒素检测等全套测试。其性能经过严谨验证,并针对细胞培养用途及临床前研究阶段的其他应用场景进行了兼容性测试。当您的研究进入后期临床阶段时,我们还提供定制化GMP蛋白服务:根据您的具体需求,我们将协同开发符合细胞治疗产品制造要求的GMP级蛋白制品,确保其满足细胞生产过程中原料及辅料的使用规范。
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
This protein contains a furin-like convertase cleavage site, 355-RQYR-358, and will be partially processed into N and C-terminal fragment with calculated MW of 38.1 kDa and 24.6 kDa respectively. The protein migrates as 30 kDa, 40 kDa and 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method / rFC method.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative
纯度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景介绍
磷脂酰肌醇蛋白聚糖-3(Glypican-3,简称GPC3)又名肠道蛋白OCI-5、GTR2-2或MXR7,属于磷脂酰肌醇蛋白聚糖家族。该蛋白在肺、肝、肾组织中高表达,能抑制二肽基肽酶IV(DPP4)的活性。GPC3可能参与调控中胚层来源组织器官的生长抑制/调节过程,并在介导胰岛素样生长因子2(IGF2)与其受体的相互作用中发挥功能调节作用。
关键字: Glypican 3;Glypican 3蛋白;GPC3重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。