性状白色结晶或结晶性粉末用途DL-肉碱盐酸盐可用于食品添加剂和辅助治疗剂。生物活性DL-肉碱盐酸盐是氨基酸赖氨酸和蛋氨酸生物合成的一种季铵化合物。体外研究ThemainroleofL-carnitineistoshuttlelong-chainfattyacidsacrosstheinnermitochondrialmembrane.AfterL-carnitineandacyl-CoAbecomeacyl-carnitinebyactivationofcarnitinepalmitoyltransferase(CPT)-I,thetransportedacyl-carnitineischangedintoacyl-CoAbyCPT-IIinthemitochondriamatrix.Palmitoyl-CoA-inducedmitochondrialrespirationisincreasedbyL-carnitinetreatment,andthenisacceleratedbythepresenceofADP.ThisaccelerationisinducedbytreatmentwithL-carnitineinaconcentration-dependentmanner,andissaturatedat5mML-carnitine.PretreatmentwithL-carnitineaugmentsNrf2nucleartranslocation,DNAbindingactivityandhemeoxygenase-1(HO-1)expressioninH2O2-treatedHL7702cells.L-carnitineprotectsHL7702cellsagainstH2O2-inducedcelldamagethroughAkt-mediatedactivationofNrf2signalingpathway.体内研究L-carnitineisfoundtodown-regulatetheubiquitinproteasomepathwayandincreaseIGF-1concentrationsinanimalmodels.L-carnitineadministrationfor2weeksofhindlimbsuspensionalleviatesthedecreaseinweightandfibersizeinthesoleusmuscle.Inaddition,L-carnitinesuppressesatrogin-1mRNAexpression,whichhasbeenreportedtoplayapivotalroleinmuscleatrophy.SimultaneoustreatmentwithL-carnitineattenuatestherenalfibrosis(whichcorrelatedwithareductionofplasmaTGF-β1levels)andthepro-oxidativeandproinflammatorystatusreportedinL-NAMEgroups,withaconcomitantincreaseintheexpressionofPPAR-γ.用途用于医药、水产饲料添加营养剂等
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