Human IL-11 R alpha Protein, His Tag (MALS verified)
分子别名(Synonym)
IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha
表达区间及表达系统(Source)
Human IL-11 R alpha, His Tag (ILR-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ala 370 (Accession # Q14626-1).
Predicted N-terminus: Ser 24
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 39.6 kDa. The protein migrates as 47-52 kDa when calibrated against Star Ribbon Pre- stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景介绍
白细胞介素-11受体(IL11)。IL6、LIF、OSM、CNTF、IL11和CT1的受体系统可利用IL6ST启动信号传导。IL11/IL11RA/IL6ST复合物可能参与调控成骨祖细胞或其他间充质细胞的增殖和/或分化(可能)。对颅面骨和牙齿的正常发育至关重要,可抑制骨缝过早闭合并调节牙齿数量。可溶性IL11受体(sIL11RA)作为IL11活性的激动剂,其与IL11形成的复合物能结合细胞表面的IL6ST/gp130,并通过"IL11反式信号传导"机制在不表达膜结合型IL11RA的细胞中诱导信号传导。
关键字: IL-11RA;IL-11RA蛋白;IL-11RA重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。